Disease and Antibodies

SLE Double stranded DNA, anti Smith
ANA


Sjogren Sx SS-A (anti Ro), SS-B (anti la),
rheumatoid factor, AA antibody


Wegener ‘s granulomatosis c-ANCA (antineutrophil cytoplasm
autoantibodies)

Graves disease to TSH receptor (thyroid stimulating)

CREST sx Anti centromere

Drug induced SLE Anti histone

Goodpasture’s disease Antiglomerular basement membrane
(IgG & complement to type IV collagen)


Sistemyc sclerosis Anti Scl-70

Mixed conective tissue disease Anti ribonucleoprotein

Myasthenia gravis Anti Ach receptor

Hashimoto’s thyroiditis Thyroglobulin & microsomal Ag

DM-1 Anti islet & anti insulin

Pernicious anemia Anti intrinsic factor

ITP IgG to platelets

Guillain Barre
**T cells vs. myelin

Multiple sclerosis Anti myelin basic protein
(also anti measles v.)


Rheumatoid arthritis IgM directed to IgG

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**note, in this situation is not an antibody

see you later


ref. kaplan, robbins.