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  1. #1
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    Actiona Potential

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    A neurophysiologist is studying the properties of various receptor subtypes, using whole cell voltage clamp recordings made from coronal brainslices. At a holding potential of -70mV,bath application of receeptor agonists for four different receptor types consistently elicited either excitatory postsynaptic currents or inhibitory postsynaptic currents.During the study of one receeptor,however,agonist application failed to elicit a postsynaptic responce at -70 mV but did elicit a reliable responce at aholding potential of 0 mV.This receptor is most likely which of the following?
    A. GABA-A
    B.Kainate
    C.Nicotine Ach
    D. NMDA
    E.Serotonin

    Actually I dont understand the question and answer of this question somebody can explain this one?

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    i guess its act nicotine receptor channels ar opned only at depolarizing potential

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    its nmda receptor this needs the dislodgment of mg+ doen by deploarisation followed by the inward moment of na+

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    Quote Originally Posted by Anonymous
    its nmda receptor this needs the dislodgment of mg+
    doen by deploarisation followed by the inward moment of na+
    You are correct. Mg2+ causes a depolarizing block; this must be
    removed by hyperpolarizing the cell (moving it farther down from 0mV).

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