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  1. #1
    herbolaryo is offline Newbie
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    Hypothyroidism, Liver Enzymes and anemia

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    One of the clinical manifestation of hypothyroidism is elevated liver enzymes and anemia.

    1. What is the mechanism of elevated liver enzymes in hypothyroism?
    2. What is the mechanism of anemia in hypothyroism?

  2. #2
    modern day Hero is offline Junior Member 510 points
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    [1] t4 is usually deiodinated to t3 by liver ( and kidneys ).
    liver failure (noted by elevated liver enzymes) would decreases the conversion of t4 to t3 and therefore the efficiency of thyroid hormone would be decreased. hypothyroidism.

    [2] hypothyroidism causes a decrease in basal metabolic rate, therefore ATP is low. in order to bring the body back to homeostasis one must increase basal metablolic rate by increasing ATP via glycolysis or 02. In order to increase 02, erythropoetin is increased to make more RBCs. More RBCs = More 02-carriers. Therefore i'd suspect it would be a normocytic anemia that would result from Hypothyroidism. i know this is a bit of a stretch so i hope someone else can post their thoughts.

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