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  1. #1
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    winston is offline Junior Member 510 points
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    Mechanism of Pain in Myocardial Infarct?

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    Pain associated with myocardial infarction is due to:
    a) Increase Sympathetic
    b) Increase Parasympathetic
    c) Increase Diastolic Pressure
    d) Increase Systolic Pressure?
    e) Increase in toxic metabolites in the heart

    I don't know the answer but i was thinking an increase in sypmathetic activity......if anyone knows for sure please post the best answer since ithink this is a fairly high yield concept.

    Thanks!
    "Anything worth doing is worth overdoing."
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    beefy is offline Member 510 points
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    Quote Originally Posted by winston View Post
    Pain associated with myocardial infarction is due to:
    a) Increase Sympathetic
    b) Increase Parasympathetic
    c) Increase Diastolic Pressure
    d) Increase Systolic Pressure?
    e) Increase in toxic metabolites in the heart

    I don't know the answer but i was thinking an increase in sypmathetic activity......if anyone knows for sure please post the best answer since ithink this is a fairly high yield concept.

    Thanks!
    answer e

    "Although several substances have been investigated as potential mediators of anginal pain, at present only two molecules have been convincingly demonstrated to be involved in the genesis of cardiac ischemic pain in man: adenosine and bradykinin....As bradykinin is released in large amounts by the heart during ischemia, it can be a natural stimulus for causing, via arachidonic acid metabolites, excitation of the sensory receptors signaling pain during myocardial ischemia."

    the other answers don't really directly correlate to pain in my opinion..

  3. #3
    omarsiag is offline Newbie 510 points
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    answer is E.

    myocardial infarction is mainly caused by damage or blockage of the coronary artery which perforates the heart tissue which will cause cyanosis which leads to myocardial infarction , full blockage of the coronary is lethal while blockage of some of its branches as the marginal branch will cause local cyanosis , then the tissue and its cells wont have a blood stream to evacuate its toxis of co2 and other nitrogenous elements causing toxication and leading to MI "myocardial infarction"

    correct me if im wrong!!!

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    modern day Hero is offline Junior Member 510 points
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    atherosclerosis = blockage of blood supply to heart
    therefore heart does not get nutrients and 02.

    whenever heart contracts it uses ATP.
    where does ATP come from? glycolysis and 02.

    since we blocked off nutrients and 02, myocytes try to make ATP by anaerobic metabolism. Anaerobic metabolism increases lactic acid production.

    increased lactic acid potentiates bradykinin.

    bradykinin = pain.


    in answer E, i'm assuming lactic acid is the toxic metabolite.

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