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    qaiser is offline Newbie 510 points
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    Carcinoma of the thyroid

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    I intended to post this topic under pathology but I dont know how it got under physiology. Could you please place it under pathology thread. Thanks
    Etiology:
    Associated with radiation to the head or neck.
    Genetic predisposition.
    Gross appearance:
    Firm nodule on the thyroid.
    Types:
    1. Follicular 2. Papillary 3. Medullary 4. Anaplastic
    Follicular type:
    Small uniform, follicles filled with colloid.

    Metastasizes to lungand bone via
    hematogenous spread.
    Papillary type:
    Comprise 75-80% of cases.

    Papillae of cuboidal cells.

    Metastasizes to local lymph nodes.

    Orphan Annie nuclei.

    Psammoma bodies.

    Has a good prognosis.
    Medullary type:
    Derived from C cells.

    Nests of cells within amyloid deposits.

    Secretes calcitonin.

    Associated with MEN IIa and IIb.
    Anaplastic type:
    Small anaplastic cells.

    Pleomorphic giant cells.

    Spindle cells.

    Has poor prognosis.
    Clinical Manifestations:
    Nodule of mass in neck.
    Dysphagia (due to tumor mass compression)
    Hoarsness (due to local compression)
    Treatment:
    Thyroidectomy or lobectomy.
    Radioactive thyroid treatment.
    Good luck in your studies.




    Last edited by qaiser; 02-11-2007 at 11:46 AM. Reason: Would like to place this post under Pathology not under physiology. Could you please help? Thanks

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