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    st_55 is offline Member 510 points
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    question

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    question: what is the difference between transferrin and ferritin levels?

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    howardhoavan is offline Member
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    transferrin

    ferritin

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    jameslynton is offline Super Moderator 48 points
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    Quote Originally Posted by st_55 View Post
    question: what is the difference between transferrin and ferritin levels?
    Good Question - Iron is transported in the plasma by transferrin - a protein that binds two molecules of ferritin and is stored inside the tissues inside molecules of ferritin. The large internal cavity (~80 A in diameter) of ferritin can hold as many as 4500 ferric ions. So these levels are indirect measures of the bodies stores of iron. These giant 90-kd molecules are controled by Ferritin mRNA which has a iron response element (IRE) - in times of low iron concentrations these molecules are not made. When iron (ferric ions increase) more are made. These are critical to the manufacture of heme in red blood cells and the cytochrome c cycles. Hope this helps - this is more Biochemistry that has effects on physiology...
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    MDiva's Avatar
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    transferrin and ferritin levels

    Here's another take on the levels:

    Transferrin is an iron transport protein. Clinical consideration: In the case of iron deficieny, transferrin levels will be high. Imagine a bunch of taxi cabs transporting a lot of people during rush hour. You can't catch a cab because none are available. However, after rush hour is over, there are available taxis everywhere because everyone is at work. No people, yet plenty of taxis around.

    Ferritin is an iron storage protein. In the case of iron deficiency, ferritin levels will be low. Consider what Jameslynton posted before about the production of ferritin: low iron, no ferritin produced. So ferritin comes around on an 'as-needed' basis.
    I used to pray and pray for a bike and never got one. Later I learned that God doesn't work that way... so I went out and stole a bike and asked God for forgiveness.

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    Good Points MDIVA. I like your use of taxi cabs waiting. Also remember these are more water soluable proteins and the iron is stored as iron oxide - hydroxide. Thus they are water soluable and their ability to move in the blood plasma - extracellular and intra celluar fluids. I would expect the only thing we have not covered is the transferrin receptor a membrane protein that binds the iron loaded transferrin and moves it inside the cell.
    Last edited by Bad_Dobby; 10-04-2006 at 08:23 PM.

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    MDiva's Avatar
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    Quote Originally Posted by Bad_Dobby View Post
    I would expect the only thing we have not covered is the transferrin receptor a membrane protein that binds the iron loaded transferrin and moves it inside the cell.

    Thanks for your good insight, Bad Dobby
    I used to pray and pray for a bike and never got one. Later I learned that God doesn't work that way... so I went out and stole a bike and asked God for forgiveness.

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    st_55 is offline Member 510 points
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    thank you all for your explanations..it was very helpful

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