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  1. #1
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    Adaptation to high altitude LUNGS

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    So what are the changes that occur in high altitude related to:

    1-ALVEOLAR Po
    2-Pulmonary vessels
    3- to 2-3 DPG concentration
    4-ventilation
    5-Hemoglobin












    1-Will decrease because of the barometric pressure is decrease= HYPOXEMIA

    2-VASOCONSTRICTION

    3-they will be increased shifting the hemoglobin O curve to the right

    4- Hyperventilation
    5-You will have polycythemia because hypoxia will stimulate the kidney to release erythroproietin
    Moderator: USMLE AND Residency Forums.

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    why even bother with the obvious. Just know where you are need it and where you can help the most.

  2. #2
    stateofequilibrium's Avatar
    stateofequilibrium is offline Super Moderator 6105 points
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    say that 10x fast! Keep up the good work, some good review.
    Posterior Fornix.

  3. #3
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    Thank you state of estateofquilibrium or may I say HOMOESTASIS
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    why even bother with the obvious. Just know where you are need it and where you can help the most.

  4. #4
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    elektra is offline Member 510 points
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    Remeber that 3 factors determine alveolar PO2
    1-Atmospheric pressure
    2-Concentration of O2
    3- PA CO2

    I like this formula to see what happend to Alveolar Po2

    PAO2 = (Patm-PH2O) FO2-PACO2/ R

    Patm= at sea level is 760 mmHg (changes occur with going to a place to high altittude or diving)
    PH2O= 47 mmHg
    FO2= Fraction of oxigen inspired, at room air = 0.21 (giving supplemental O2 will increase FO2)
    PACO2= alveolar pressure of CO2 = 40 mmHg
    R= Is the respiratory exchange ratio wich normally is 0.8

    So it is so simple only follow the formula

    a Increase of PCO2 will decrese the PAO2
    a decrease in atmospheric pressure (high alttitude) will decrese the PAO2
    a increase of inspire oxigen concentration will increase PAO2
    Last edited by elektra; 04-04-2006 at 10:57 AM.
    Elektra

  5. #5
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    Very Good Reply
    Moderator: USMLE AND Residency Forums.

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