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  1. #1
    usmlethinking is offline Junior Member 510 points
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    4 year old with diarrhea and abdominal distention. Stools show Giardia. DOC is?

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    A 4-year-old white male who has diarrhea and abdominal distention is brought to your office. Laboratory examination of the stools reveals Giardia lamblia trophozoites.

    In treating this patient, the drug of choice is

    a.metronidazole
    b.chloroquine
    c.furazolidine
    d.sulfasalazine

  2. #2
    Unregistered Guest
    Metronidazole

  3. #3
    usmlethinking is offline Junior Member 510 points
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    That is correct

    Quote Originally Posted by Unregistered
    Metronidazole
    Yes, that is correct.

    Metronidazole is a synthetic antibacterial and antiprotozoal agent that belongs to the nitroimidazole class. It is effective therapy against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. In addition, it is one of the most effective drugs available against anaerobic bacterial infections. Metronidazole is also useful in treating Crohn's disease, antibiotic-associated diarrhea, and rosacea.

    Mechanism of Action: Metronidazole is amebicidal, bactericidal, and trichomonicidal. Unionized metronidazole is readily taken up by anaerobic organisms and cells. Its selectivity for anaerobic bacteria is a result of the ability of these organisms to reduce metronidazole to its active form intracellularly. The electron transport proteins necessary for this reaction are found only in anaerobic bacteria. Reduced metronidazole then disrupts DNA's helical structure, thereby inhibiting bacterial nucleic acid synthesis. This eventually results in bacterial cell death. Metronidazole is equally effective against dividing and nondividing cells.
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