Rheumatoid factors are Anti IgG antibodies created against Fc portion of body's own IgG immunoglobulins in Rheumatoid arthritis and some other diseases. What I fail to understand is that how come antibodies are produced against body's own IgGs at first place ? I mean how can our body break self-tolerance for something like IgG which it encounters all the time (how can it consider its own IgG as "foreign").
Secondly, when AntiIgG antibodies are created shouldn't they destroy all the IgGs in body leading to an immunocompromised state..?
All this Rheumatoid factor thing confuses me a lot.