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  1. #1
    pplpaul is offline Newbie 510 points
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    rh isoimmunization vs polyhydramnios

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    could some people explain"how does rh isoimmunization result in polyhydramnios?" ? thanks.

  2. #2
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    Thats new for me?????
    Moderator: USMLE AND Residency Forums.

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    why even bother with the obvious. Just know where you are need it and where you can help the most.

  3. #3
    wcb22 is offline Elite Member
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    The sensitized mother produces IgG anti-D (antibody) that crosses the placenta and coats D-positive fetal red cells which are then destroyed in the fetal spleen.
    Mild to moderate hemolysis (red cell destruction) manifests as increased indirect bilirubin (red cell pigment).
    Severe hemolysis leads to red blood cell production by the spleen and liver.
    • Subsequently, hepatic circulatory obstruction (portal hypertension) with placental edema interferes with placental perfusion and ascites develops.[5]
    • Hepatomegaly, increased placental thickness, and polyhydramnios often precede the development of hydrops (fetal heart failure).[5]
    • As liver damage progresses decreased albumin production results in the development of anasarca, and effusions.

  4. #4
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    WCB22, your the best.
    thanks
    Moderator: USMLE AND Residency Forums.

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    why even bother with the obvious. Just know where you are need it and where you can help the most.

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