Vancomycin & Aminoglycoside Pharmacokinetics
Patient Information:
Drug : Calculation :
Drug Infusion Time :
Current Weight : Admit Weight :
Gender :
Age : years Serum Creatinine : mg/dL
Height :
inches
Vancomycin Clearance :

References:
Young, Lloyd Y., and Koda-Kimble, Mary A. Applied Therapeutics: The Clinical Use of Drugs. 6th Edition. Vancouver: Applied Therapeutics, Inc., 1995.
Equations:
Initial Bolus-Model Equations Initial Short-Infusion Equations
Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)
Cpss max (mg/L) =
 Dose ( e - kt ) Vd

( 1 - e - kt )
Cpss min (mg/L) =
 Dose ( e - kt ) Vd

( 1 - e - kt )
Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)
Cpss max (mg/L) =
 Dose ( 1 - e - ktin )   x  e - kt1 tin x Cl

( 1 - e - kt )
Cpss min (mg/L) =
 Dose ( 1 - e - ktin )   x  e - kt2 tin x Cl

( 1 - e - kt )
Revision Bolus-Model Equations Revision Short-Infusion Equations
Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)
kel =
ln(
 dose / Vd + C (trough) C (trough)
)

t
Dose (mg) =
 Cpss x Vd x ( 1 - e - kt ) e - kt
Cpss max (mg/L) =
 Dose ( e - kt ) Vd

( 1 - e - kt )
Cpss min (mg/L) =
 Dose ( e - kt ) Vd

( 1 - e - kt )
Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)
kel =
ln(
 Cpss (peak) Cpss (trough)
)

Dt
Cl (L/hr) =
 Dose ( 1 - e - ktin )  x  e - kt Cpss x tin

( 1 - e - kt )
Dose (mg) =
 Cpss x Cl x tin x ( 1 - e - kt ) ( 1 - e - ktin) ( e - kt )
ss max (mg/L) =
 Dose ( 1 - e - ktin )   x  e - kt1 tin x Cl

( 1 - e - kt )
Cpss min (mg/L) =
 Dose ( 1 - e - ktin )   x  e - kt2 tin x Cl

( 1 - e - kt )

DISCLAIMER
DISCLAIMER: All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither ValueMD nor any other party involved in the preparation or publication of this site shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.