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    usmlemate is offline Junior Member
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    Oral Hairy Leukoplakia

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    A 35-year-old HIV-infected man with a CD4 count of 100 cells/mm3 visits the clinic for a routine appointment. On examination, white papular lesions are observed bilaterally on the lateral aspect of his tongue (Figure 1 and Figure 2). These white lesions are presumptively diagnosed as oral hairy leukoplakia.

    Which of the following statements is TRUE regarding oral hairy leukoplakia?

    A. It occurs in approximately 5% of persons infected with hepatitis C virus (who are not co-infected with HIV).

    B. It is caused by infection with human herpes virus type 8 (HHV-8).

    C. It is caused by infection with Epstein-Barr virus.

    D. Approximately 15% of lesions develop into premalignant lesions that require surgical removal.

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    Asclepius1 is offline Ultimate Member 537 points
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    answer

    it cuase by EBV answer c ,good question!

  3. #3
    usmlemate is offline Junior Member
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    Re: answer

    Quote Originally Posted by drsmastoori
    it cuase by EBV answer c ,good question!
    Answer C is correct. Very good!

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    usmlemate is offline Junior Member
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    Re: Oral Hairy Leukoplakia

    Quote Originally Posted by usmlemate
    A 35-year-old HIV-infected man with a CD4 count of 100 cells/mm3 visits the clinic for a routine appointment. On examination, white papular lesions are observed bilaterally on the lateral aspect of his tongue (Figure 1 and Figure 2). These white lesions are presumptively diagnosed as oral hairy leukoplakia.

    Which of the following statements is TRUE regarding oral hairy leukoplakia?

    A. It occurs in approximately 5% of persons infected with hepatitis C virus (who are not co-infected with HIV).

    B. It is caused by infection with human herpes virus type 8 (HHV-8).

    C. It is caused by infection with Epstein-Barr virus.

    D. Approximately 15% of lesions develop into premalignant lesions that require surgical removal.

    Answer C is correct. Multiple studies throughout the years have clearly shown that Epstein-Barr virus is the causative agent of oral hairy leukoplakia.

    Answer A is incorrect. Although reports have documented rare cases of oral hairy leukoplakia in persons without HIV infection, this disorder has rarely, if ever, has been observed in HIV-negative persons infected with hepatitis C virus. Oral lichen planus, however, has been suggested to occur more frequently in patients with hepatitis C.

    Answer B is incorrect. Although human herpes virus type-8 virus can be found in the oral mucosa of persons infected with HIV, there is no evidence that it plays a role in causing oral hairy leukoplakia. This virus, however, is the causative agent of Kaposiís sarcoma.

    Answer D is incorrect. Although oral hairy leukoplakia is an excellent marker of immune suppression, it rarely causes clinical symptoms. There is no evidence that these lesions are premalignant or are associated with any other oral lesion.

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