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  1. #1
    usmlemate is offline Junior Member
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    Kaposi's Sarcoma

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    A 32-year-old HIV-infected man presents to clinic having noticed reddish-brown nodular lesions on his skin (Figure 1). His risk factor for acquisition of HIV is having sex with other men, his CD4 count is 230 cells/mm3, and he has never taken antiretroviral agents. A biopsy confirms Kaposi's sarcoma.

    Which of the following is TRUE regarding Kaposi's sarcoma?

    A. In some patients, highly active antiretroviral therapy alone causes significant improvement of Kaposi's sarcoma lesions.

    B. Human herpes virus type 6 (HHV-6) is the causative agent of Kaposi's sarcoma.

    C. Visceral, but not isolated cutaneous Kaposi's sarcoma, is an AIDS-defining illness.

    D. Liquid nitrogen cryotherapy is generally ineffective for management of localized cutaneous Kaposi's sarcoma lesions.

  2. #2
    usmlemate is offline Junior Member
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    Re: Kaposi's Sarcoma

    Quote Originally Posted by usmlemate
    A 32-year-old HIV-infected man presents to clinic having noticed reddish-brown nodular lesions on his skin (Figure 1). His risk factor for acquisition of HIV is having sex with other men, his CD4 count is 230 cells/mm3, and he has never taken antiretroviral agents. A biopsy confirms Kaposi's sarcoma.

    Which of the following is TRUE regarding Kaposi's sarcoma?

    A. In some patients, highly active antiretroviral therapy alone causes significant improvement of Kaposi's sarcoma lesions.

    B. Human herpes virus type 6 (HHV-6) is the causative agent of Kaposi's sarcoma.

    C. Visceral, but not isolated cutaneous Kaposi's sarcoma, is an AIDS-defining illness.

    D. Liquid nitrogen cryotherapy is generally ineffective for management of localized cutaneous Kaposi's sarcoma lesions.
    The correct answer is A. Several reports have noted marked improvement or resolution of Kaposi's sarcoma lesions in response to highly active antiretroviral therapy. Most of these reports have involved protease inhibitor-based regimens.

    B is incorrect. Multiple lines of evidence have now established that human herpes virus type 8 (HHV-8), not HHV-6 is the causative agent of Kaposi's sarcoma.

    C is incorrect. Any form of Kaposi's sarcoma, cutaneous or visceral, is an AIDS-defining illness.

    D is incorrect. Cutaneous Kaposi's sarcoma lesions can be treated by liquid nitrogen cryotherapy, intralesional chemotherapy, radiation therapy, or a combination of these modalities. The choice of therapeutic options depends on the pattern of involvement in the individual patient.

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