Which of the following lipoprotein abnormalities confers a definite risk for coronary heart disease?
A. Increased low-density lipoprotein (LDL) cholesterol
B. Increased total cholesterol
C. Increased high-density lipoprotein (H DL) cholesterol
D. Increased chylomicron triglyceride
E. Decreased lipoprotein(a)

The correct answer is A
Educational Objectives
Recognize atherogenic lipoprotein abnormalities.
Increased LDL cholesterol is the lipoprotein abnormality that confers the greatest and most consistent risk for coronary heart disease. An increased total cholesterol does not allow the prediction of risk because multiple lipoprotein abnormalities may contribute to an elevated total cholesterol, including an increased HDL cholesterol. An increased HDL cholesterol lowers the risk for coronary heart disease. Although an elevated chylomicron triglyceride level may contribute to the development of pancreatitis, it is not predictive of coronary heart disease.