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  1. #1
    hunteradam07 is offline Permanently Banned 511 points
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    Most common cause of osteomyelitis in sickle cells amenia!

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    This seems a straight forward question: What is the most common cause of osteomyelitis in Sickle cells amenia (SCA) pts?
    I thought it was still S. Aureus, because it's the mcc of osteomyelitis in any population and the Dr. Condrad said as much in his videos. He even states that Salmonella causing osteomyelitis is higher prevelence in SCA but Staph still most common cause!
    Mean while i saw the same question on UW, and it's said that Salmonella is the mcc osteomyelitis in SCA up to 70% of the case.
    Can anyone confirm this?

  2. #2
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    minimi mo like daughterly says you have a 50/50 chance there.
    But yes is better to get it right.
    Moderator: USMLE AND Residency Forums.

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    why even bother with the obvious. Just know where you are need it and where you can help the most.

  3. #3
    jguru2 is offline Member 510 points
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    Sca

    Quote Originally Posted by hunteradam07 View Post
    This seems a straight forward question: What is the most common cause of osteomyelitis in Sickle cells amenia (SCA) pts?
    I thought it was still S. Aureus, because it's the mcc of osteomyelitis in any population and the Dr. Condrad said as much in his videos. He even states that Salmonella causing osteomyelitis is higher prevelence in SCA but Staph still most common cause!
    Mean while i saw the same question on UW, and it's said that Salmonella is the mcc osteomyelitis in SCA up to 70% of the case.
    Can anyone confirm this?
    Staph is still the MCC in normal hosts; in SCA it is about 40% of the cases only, but salmonella is still the mcc of osteomyelitis in SCA.

    One prospective study for septic arthritis in SCA showed Staph as the most common infecting organism, and salmonella only in about 14% of the cases.

    TI - Salmonella osteomyelitis and the hand-foot syndrome in sickle cell disease. AU - ******* OM

    TI - Retrospective review of osteoarticular infections in a pediatric sickle cell age group. AU - Chambers JB; Forsythe DA; Bertrand SL; Iwinski HJ; Steflik DE SO - J Pediatr Orthop 2000 Sep-Oct;20(5):682-5

    TI - Etiology of osteomyelitis complicating sickle cell disease.
    AU - Burnett MW; Bass JW; Cook BA
    SO - Pediatrics 1998 Feb;101(2):296-7.

    Hook, EW, Campbell, CG, Weens, HS, Cooper, GR. Salmonella osteomyelitis in patients with sickle-cell anemia. N Engl J Med 1957; 257:403. SO - J Pediatr Orthop 1992 Jul-Aug;12(4):534-8.
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  4. #4
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    dr.kirk is offline Junior Member 510 points
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    Just had a Uworld question on it. It said most (like 70% of cases) causes of osteomyelitis in sickle cell pts is Salmonella. Most common cause in general population is Staph Aureus.

  5. #5
    jey2283 is offline Junior Member 510 points
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    just had the same question on UW. I'm going with Conrad on this age old question. The man said "S. Aureus is the MCC of osteomyleitis in all populations." This is much like then pneumonia- klebsiella- alcoholic question..#1 cause is still strep pneumo.

  6. #6
    Agboola Lai is offline Newbie 510 points
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    It's quite tricky but this is the correct answer. S. aureus is the commonest cause of osteomyelitis in SCD however, salmonella, if producing osteomyelitis is most commonly seen in patient with SCD.

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