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  1. #1
    doctorchamita is offline Newbie
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    B2 agonist vs cromolyn sodium?

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    which one to give in exercise induces asthma?
    Kaplan notes: cromolyn sodium?
    Swanson Q's (family practice) : B2 agonist?


    Thanks

  2. #2
    drnick is offline Newbie 510 points
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    B2 Agonist vs. Cromolyn Sodium for EIB

    Identifying Exercise-Induced Bronchospasm
    Treatment Hinges on Distinguishing It From Chronic Asthma
    Christian L. Hermansen, MD; Jeffrey T. Kirchner, DO
    THE PHYSICIAN AND SPORTSMEDICINE - VOL 33 - NO. 12 - DECEMBER 2005

    "The hallmark of pharmacologic treatment for EIB is short-acting bronchodilators such as beta-agonists.1,15 Many patients prefer these medications, such as albuterol, because they require administration only before exercise to control symptoms. Two to four puffs taken 15 minutes before exercise provide about 4 hours of relief. Side effects of beta-agonists include palpitations, tachycardia, and tremors, but these usually are mild. Tolerance to beta-agonists can develop if they are used often and in the long term.

    Mast cell stabilizers are sometimes used as second-line therapy for EIB. These agents work by preventing leukocyte degranulation and resultant histamine release. Examples of such drugs include cromolyn sodium (Intal) and nedocromil sodium (Tilade). Patients take the medication 15 to 60 minutes before exercise, and its benefits last about 4 hours. A recent Cochrane review of nedocromil sodium use to prevent EIB19 showed it improved forced expiratory volume in 1 second (FEV1) by an average of 16% and shortened the duration of EIB symptoms to less than 10 minutes.

    Longer-acting beta-agonists are another option for patients with EIB. Salmeterol (Serevent) has been shown to significantly improve FEV1.20,21 When these medications are taken 30 minutes before activity, they can provide relief for up to 12 hours, making them good treatment options for athletes whose exertion is prolonged.19 However, long-term use seems to shorten the duration of action.21,22"

  3. #3
    doctorchamita is offline Newbie
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    Thanks a lot !!

  4. #4
    draft is offline Junior Member 510 points
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    Beta agonists are rapid acting and short acting, use in acute exacerbations.

    Cromolyn is a mast cell stabilizer, its used to prevent not treat attacks.

  5. #5
    usmlethinking is offline Junior Member 510 points
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    there is a short acting beta agonist and there is a long acting beta agonist. short acting= albuterol. half life =4 hours. use Q4 hours as needed. good asthma rescue medicine.

    Long acting beta agonist=salmeterol. half life=10 hours. Use BID. Use in combination with fluticasone to make Advair Diskus.

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