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  1. #1
    doc99 is offline Junior Member
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    q

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    a young african american male patient presents with UTI symptoms and when u admin tri-metoprime sulfametoxazole for treatment ,he develops a hemolytic anemia crise.whith further evaluation u find that his brother and his causin(male)also have similar problem with this drug and some certain foods.which one is NOT affected by this dis?
    1-fatty acids biosynthesis
    2-cholestrol synthesis
    3-nucleotide synthesis
    4-oxygen dependent killing bacteria with PMNs
    5-protein biosynthesis(translation)

  2. #2
    Unregistered Guest

    Glucose 6 Phosphate dehydrogenase deficiency

    the patient apparently has G-6-P-D deficiency, a genetic disease that is triggered by some agents, as sulfas. This deficiency produce an impaired production of NADPH (G-6-P Dehydrogenase is the enzyme that catalyzes the commited step in the pentose phosphate cycle). I do not think that the production of pentoses is very affected since pentoses can be produced by the reversible phase of pentose phosphates shunt, without the intervention of G6P Dehydrogenase.

  3. #3
    nabothian is offline Newbie 510 points
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    the answer is protein synthesis i guess.translation doesnot require nadph.

  4. #4
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    Monsoonrain is offline Member 510 points
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    Yes, Protein synthesis doesn't required NADPH.

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