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  1. #1
    Asclepius1's Avatar
    Asclepius1 is offline Ultimate Member 537 points
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    Help with explanations Prader Willi/Angelmans Sundr.

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    1. What is meant excactly with Imprinting and how is this shown in Prader-Willi or Angelmans (does it mean the offspring only get chromosome 15 from only one of the parents and therefore is missing the other chromosome 15?)
    2.What is the underlying genetic or biochemistry that happen on the number 15 chromosomes (meaning what is the primary defect ? )

  2. #2
    uce2go is offline Junior Member
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    one of the chromosome 15 is inactivated normally by the father and the other suffers a mutation in Prader Willie, so then both chromosomes are inactivated.

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    Monsoonrain's Avatar
    Monsoonrain is offline Member 510 points
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    It's actually due to microdeletion of chomosome 15. It could be inherited either from father or mother with completely different phenotypical expression. When from Father it's called prader-willie syndrome and if from mother, it's called Angelman syndrome.

  4. #4
    halli Guest
    This is called imprinting!

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