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  1. #1
    BioPatel is offline Member
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    chronic alcoholic compared to a non-drinker

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    Which of the following metabolic alterations would most likely be present in a chronic alcoholic compared to a non-drinker?

    A. Fatty acid oxidation is stimulated
    B. Dihydroxyacetone phosphate formation is favored over glycerol-3-phosphate formation
    C. Gluconeogenesis is stimulated
    D. The ratio of lactate to pyruvate is decreased
    E. The ratio of NADH to NAD+ is increased

  2. #2
    BioPatel is offline Member
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    The correct answer is E. The principal route of metabolism of ethanol is via alcohol dehydrogenase, which uses hydrogen from ethanol to form NADH from NAD+, markedly increasing the ratio of NADH to NAD+. The relative excess of NADH has a number of effects, including inhibiting, rather than stimulating fatty acid oxidation (choice A); inhibiting gluconeogenesis rather than stimulating it (choice C); favoring the formation of glycerol-3-phosphate over dihydroxyacetone phosphate (compare with choice B); and favoring the formation of lactate rather than pyruvate from glycolysis (thereby increasing, rather than decreasing the lactate/pyruvate ratio; choice D).

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    usmlerock is offline Newbie
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    E is the ans

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