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    BioPatel is offline Member
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    Urine of a pregnant woman shows positive Clinitest reaction

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    Urine screening of an apparently healthy pregnant woman demonstrates a positive Clinitest reaction. However, blood glucose levels were within normal limits, and more specific testing for urine glucose is negative. The woman has been unaware of any metabolic problems and has been living a normal life. Deficiency of which of the following enzymes would most likely produce this presentation?

    A. Fructokinase
    B. Fructose 1-phosphate aldolase
    C. Galactose 1-P-uridyl transferase
    D. Lactase
    E. Pyruvate dehydrogenase

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    Asclepius1 is offline Ultimate Member 537 points
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    Guess is B

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    BioPatel is offline Member
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    Re: Urine of a pregnant woman shows positive Clinitest reaction

    Quote Originally Posted by BioPatel
    Urine screening of an apparently healthy pregnant woman demonstrates a positive Clinitest reaction. However, blood glucose levels were within normal limits, and more specific testing for urine glucose is negative. The woman has been unaware of any metabolic problems and has been living a normal life. Deficiency of which of the following enzymes would most likely produce this presentation?

    A. Fructokinase
    B. Fructose 1-phosphate aldolase
    C. Galactose 1-P-uridyl transferase
    D. Lactase
    E. Pyruvate dehydrogenase
    The correct answer is A. Glucose, galactose, and fructose are all reducing sugars, and elevations of all of these sugars can be detected with Clinitest tablets. Neither lactose nor pyruvate can be detected, thus eliminating lactase and pyruvate dehydrogenase as plausible choices. This leaves three possibilities: fructokinase, fructose 1-phosphate aldolase, and galactose 1-P-uridyl transferases. Of these, only fructokinase deficiency produces a mild (usually completely asymptomatic) condition known as fructosuria.
    Fructose 1-phosphate aldolase deficiency (choice B) produces severe hereditary fructose intolerance.

    Galactose 1-P-uridyl transferase deficiency (choice C) produces classic galactosemia.

    Lactase deficiency (choice D) produces lactose intolerance.

    Pyruvate dehydrogenase deficiency (choice E) produces severe disease (e.g., a subset of Leigh's disease).

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