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    BioPatel is offline Member
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    enzyme deficiency

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    A baby that was apparently normal at birth begins to show a delay in motor development by 3 months of age. At one year of age, the child begins to develop spasticity and writhing movements. At age three, compulsive biting of fingers and lips and head-banging appear. At puberty, the child develops arthritis, and death from renal failure occurs at age 25. This patient's condition is due to an enzyme deficiency in which of the following biochemical pathways?

    A. Ganglioside metabolism
    B. Monosaccharide metabolism
    C. Purine metabolism
    D. Pyrimidine metabolism
    E. Tyrosine metabolism

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    Asclepius1 is offline Ultimate Member 537 points
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    D. Pyrimidine metabolism s it Leschman disea?

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    BioPatel is offline Member
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    Re: enzyme deficiency

    Quote Originally Posted by BioPatel
    A baby that was apparently normal at birth begins to show a delay in motor development by 3 months of age. At one year of age, the child begins to develop spasticity and writhing movements. At age three, compulsive biting of fingers and lips and head-banging appear. At puberty, the child develops arthritis, and death from renal failure occurs at age 25. This patient's condition is due to an enzyme deficiency in which of the following biochemical pathways?

    A. Ganglioside metabolism
    B. Monosaccharide metabolism
    C. Purine metabolism
    D. Pyrimidine metabolism
    E. Tyrosine metabolism
    The correct answer is C. The patient has a classical case of Lesch-Nyhan syndrome, an X-linked disorder due to severe deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyl transferase (HPRT). This defect is associated with excessive de novo purine synthesis, hyperuricemia, and the clinical signs and symptoms described in the question stem. The biochemical basis of the often striking self-mutilatory behavior (which may require restraints and even tooth extraction) has never been established. Treatment with allopurinol inhibits xanthine oxidase and reduces gouty arthritis, urate stone formation, and urate nephropathy. It does not, however, modify the neurologic/psychiatric presentation.

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