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  1. #1
    darkmansaad's Avatar
    darkmansaad is offline Senior Member 522 points
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    Step 1 biochem vs UW biochem

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    Just wondering exactly the disparity between the two. Cuz i am getting murdered on UsmleWorld biochem like 60% i think and am wondering if i have to know obscure details about TCA cycle...for example I had no idea that methylmalonyl CoA was isomerized in a B12 dependent reaction to Succinyl CoA ....or maybe im an idiot i dont know. Possibly both.

    input?

  2. #2
    madeeha khan is offline Newbie 510 points
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    UW is very detailed but i think if we spent some time on it it can help us score in obscure questions

  3. #3
    IMG SURVIVOR's Avatar
    IMG SURVIVOR is offline Moderator 536 points
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    1-Fa will cover the easy things.
    2-UW will cover the hard things and will make you think.
    When you take the test, the questions that are under that level of difficulty you will be able to answer them. Also just by using the knowledge you gain from those questions you will be able to answer other Bioch. questions on the test.
    Moderator: USMLE AND Residency Forums.

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    why even bother with the obvious. Just know where you are need it and where you can help the most.

  4. #4
    certified is offline Newbie 510 points
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    succinyl CoA

    Quote Originally Posted by darkmansaad View Post
    Just wondering exactly the disparity between the two. Cuz i am getting murdered on UsmleWorld biochem like 60% i think and am wondering if i have to know obscure details about TCA cycle...for example I had no idea that methylmalonyl CoA was isomerized in a B12 dependent reaction to Succinyl CoA ....or maybe im an idiot i dont know. Possibly both.

    input?

    hey,
    the reason thats important is more to do with B12 deficiency , its in FA biochem vitamin section pg 80 (2007 edition), its pretty highyield...the thing i find about UW, they test these HY facts but in the most absurd way,

    but succinyl CoA can enter the heme synthesis pathway or TCA cycle
    and the build up of methylmalonyl CoA and proplonyl CoA are supposed to cause demylination, which is why u have neurologic sx's with B12 def Vs. B6

    but i totaly agree with you on UW sometimes when im going through q's i have this rxn ->

    (A)propionyl CoA carboyxylase (biotin cofactor)

    (B)methylmanlonyl mutase(b12)


    propionyl-CoA---------------->methylmalonyl CoA------>succinyl CoA

    (so i cant figure out how to put the enzymes over the arrows, but
    (A) is the enzyme responsible for propionyl-CoA to methylmalonyl CoA
    (B) is responsible for methylmalonyl CoA to succinyl CoA)

    hope that makes sense , golijan does a good job too in his vitamin section

  5. #5
    onetime is offline Newbie 510 points
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    Thanks

    Thanks! That's a good way to think of it.

  6. #6
    chaimaa is offline Junior Member 510 points
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    yes it is bravo

  7. #7
    Can2carib is offline Member 534 points
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    I think you meant neurological sx with B12 and not Folate. B6 deficiency and overdose cause peripheral neuropathies (i.e. isoniazid therapy).

  8. #8
    babypurple77 is offline Junior Member 510 points
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    thats a good point ha..tnx

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