(A) a substitution mutation changes only one specific amino acid of the protein coded
(B) a codon codes for one specific amino acid
(C) deletions or insertions cause frame-shifts starting at the codon for the amino acid affected
(D) the sum of purines in double-stranded DNA is equal to the sum of pyrimidines
(E) most of the 64 possible base triplets have been shown to code for amino acids
1. Proof that the genetic code is degenerate
2. Proof that the genetic code is nonoverlapping
3. Proof that the sequence of bases in DNA is read sequentially from a fixed starting point