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  1. #1
    YuQX is offline Junior Member 510 points
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    Question for Retinoic Acid

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    Several clinical trials have suggested that retinoic acid can induce remission in patients with acute promyelocytic leukemia. Such remission is related to the ability of retinoic acid to promote which of the following?

    A) Differentiation of leukemic cells

    B) Differentiation of monocytes into macrophages

    C) Generation of cytotoxic T lymphocytes

    D) Production of interferon

    E) Repair of DNA damage

  2. #2
    md90's Avatar
    md90 is offline Senior Member
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    goljan answers this...

    Several clinical trials have suggested that retinoic acid can induce remission in patients with acute promyelocytic leukemia. Such remission is related to the ability of retinoic acid to promote which of the following?
    A) Differentiation of leukemic cells

    B) Differentiation of monocytes into macrophages
    C) Generation of cytotoxic T lymphocytes
    D) Production of interferon
    E) Repair of DNA damage


    If you have the Goljan's Rapid Review Pathology... it's page 150, and he talks about it in his lectures. Acute Promyelocytic Leukemia is associated with an abnormality in retinoic acid metabolism therefore high doses of Vitamin A may induce remission by maturing the cells.
    Last edited by md90; 07-24-2006 at 11:36 AM.
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  3. #3
    YuQX is offline Junior Member 510 points
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    Thank you, md90!
    I checked the book, so the answer is A.

  4. #4
    md90's Avatar
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    yes... I thought that I had bolded the answer.. but must have forgotten... sorry about that.. will change that right now..
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  5. #5
    stranger2 is offline Junior Member
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    that was a qtion in NMBE one

  6. #6
    YuQX is offline Junior Member 510 points
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    I didn't realize you bolded A. Thank you again!

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