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  1. #1
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    alpha2 macroglobulin?

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    alpha2 macroglobulin is senthysized by what?
    "understanding like frindship takes time to develop"

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    md90's Avatar
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    this is my thought...

    alpha2 macroglobulin is senthysized by what?
    Alpha2-macroglobulin is a protein, and most proteins are synthesized in the liver.. so that would be my guess..
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  3. #3
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    most proteins are synthesized in the liver
    except:
    Ig by lymphocyte
    apolipprotein by enterocyte

    I am asking because i raed that :
    it is produced by Hepatocyte & Macrophage
    and it doesn't seem right
    "understanding like frindship takes time to develop"

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    md90's Avatar
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    this is what I found...

    Alpha 2 microglobulin is part of the lipocalin family. There are many different isoforms which exhibit extensive homology. It is a major urinary protein in male rats and is synthesised and secreted by hepatic parenchymal cells. Alpha 2 microglobulin is also known as MUP (major urinary protein) and is a very important allergen because it constitutes approximately 30% of the total protein content excreted in the urine. Rats are the most frequently used laboratory animals and allergy to them constitutes an occupational disease. Approximately 20 % of the personal engaged in work with laboratory animals have acquired symptoms of allergy.
    reference: http://www.abcam.com/index.html?datasheet=27160
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  5. #5
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    at the begining i was confused;
    Alpha 2 microglobulin is also known as MUP (major urinary protein)
    whaaaaaaaaaaaat? it never excreted in urine for its large size
    then i noticed:
    Alpha 2 microglobulin
    its macro not micro

    thank you anyway, i think i'll satisfy by:
    Alpha2-macroglobulin is a protein, and most proteins are synthesized in the liver..
    but i still not certain about the MACROPHAGE involvement
    "understanding like frindship takes time to develop"

  6. #6
    md90's Avatar
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    apologize... for the typo..


    I apologize for the typo.. but look on the positive side, now we both know what Alpha-2-microglobin is, along with Alpha-2-macroglobin....

    Alpha-2 macroglobulin is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. Alpha-2 macroglobulin levels are increased in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. Because of its size, α2-macroglobulin is retained in the bloodstream. Increased production of all proteins means α2-macroglobulin concentration increases. This increase has little adverse affect on the health, but is used as a diagnostic clue. Longstanding chronic renal failure can lead to amyloid by alpha-2 macroglobulin (see main article: amyloid). A common variant (29.5%) (polymorphism) of α2-macroglobulin leads to increased risk of Alzheimer's disease, although the mechanism is unknown
    In relation to macrophages:
    Alpha-2-macroglobulin is a protease-inhibitor, which is synthesized by macrophages and has a wide spectrum of inhibitory abilities.
    Macrophages secrete alpha 2-macroglobulin (alpha 2M), a protein that may facilitate early Ag handling. alpha 2M is able to entrap and form covalent linkages with diverse proteins during a transient proteinase- activated state
    It appears from the resources that I checked that alpha-2-macroglobulin plays an immunologic role; Macrophages synthesizes this protein to help with the preparation before presenting to the T-cells.

    Hope that this helps... If anyone in the forum knows more, please inform. Thank you
    Last edited by md90; 06-04-2006 at 01:01 PM.
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

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