from UES youd have to take a green line train to Grand Central, then take the 7 or shuttle to Penn Station, then take the Long Island railroad to Hicksville station, then take a bus to NUMC. It's at least a 1.5 hour trip. Also budget for a unlimited Metro card for the subway/bus ($104) and unlimited LIRR card (i think $200...not sure.)
Having said that, I know a couple of residents that did it, and you can get a lot of work done on the train. Plus who the hell wants to live in East Meadow?