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Asclepius1
05-15-2005, 04:04 PM
A neurophysiologist is studying the properties of various receptor subtypes, using whole cell voltage clamp recordings made from coronal brainslices. At a holding potential of -70mV,bath application of receeptor agonists for four different receptor types consistently elicited either excitatory postsynaptic currents or inhibitory postsynaptic currents.During the study of one receeptor,however,agonist application failed to elicit a postsynaptic responce at -70 mV but did elicit a reliable responce at aholding potential of 0 mV.This receptor is most likely which of the following?
A. GABA-A
B.Kainate
C.Nicotine Ach
D. NMDA
E.Serotonin

Actually I dont understand the question and answer of this question somebody can explain this one?

Asclepius1
05-19-2005, 10:39 AM
i guess its act nicotine receptor channels ar opned only at depolarizing potential

Asclepius1
05-19-2005, 11:51 AM
its nmda receptor this needs the dislodgment of mg+ doen by deploarisation followed by the inward moment of na+

Asclepius1
05-29-2005, 10:48 PM
its nmda receptor this needs the dislodgment of mg+
doen by deploarisation followed by the inward moment of na+

You are correct. Mg2+ causes a depolarizing block; this must be
removed by hyperpolarizing the cell (moving it farther down from 0mV).







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