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Asclepius1
04-06-2005, 10:37 PM
A 2 year old girl is brought to the emergency department 90 minutes after ingesting a drug from her mother's purse. On arrival, the child is sedated, respirations and blood pressure are normal. Which of the following drugs is most likely to reverse the sedation?a) acetylcysteineb)amyl nitratec)apomorphined)atropinee)flumazenilf)halope ridolg)naloxone

Asclepius1
04-10-2005, 10:09 PM
e)flumazenil ???

Asclepius1
05-18-2005, 10:14 AM
The drug is most likely Benzodizepine since it is used as a sleep-inducer.
It has fewer toxicity than Barbiturates. And flumazenil is its antidote.

UnregisteredUnregistered
05-26-2006, 12:17 PM
Benzos tend to cause respiratory depression, therefore ruling out Benzos and Flumazenil. Opiates, on the other hand, cause sedation w/o resp depression. This might suggest Naloxone as an antidote to something like Apomorphine.

rainz
06-04-2006, 01:22 AM
flumazenil...its in kaplan

md90
06-04-2006, 12:31 PM
We all know that Flumazenil is the antidote for Benzodiazepines.. but..
1. mechanism of action?
2. onset of action and peak effect?
3. which has the longer half-life, benzodiazepines or flumazenil?














1. Flumazenil--competitive inhibitors at the GABA-A receptor
2. onset of action--rapid and within 1-2 minutes; peak effect--6-10 minutes
3. Benzodiazepines have longer half-lives therefore repeat doses may be required..

md90
06-04-2006, 12:42 PM
What makes the other answers (acetylcysteine, apomorphine, amyl nitrate, atropine, haloperidol) wrong?














Acetylcysteine--antidote for acetaminophen overdose (Liver toxicity)
Amyl nitrate--vasodilator, tx of CN poisoning to make cyanomethemoglobin (will affect the Oxygen saturations)
Atropine--treat for bradycardia (increase heart rate)
Haloperidol--antipsychotic medication, decrease BP
Apomorphine--morphine derivative, tx for parkinson's, erectile dysfunction, and heroin addiction; at higher doses used as emetic; nalaxone is antidote;

**please add, comment, and/or correct.. thank you..:p







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