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pharmacology
02-22-2005, 05:53 PM
A 67-year-old woman is brought to the emergency department
withcomplaints of persistent fever, malaise, and the recent appearance
of amalar "butterfly" rash on the face, as well as numerous oral
ulcers.The patient states that she is taking one medication for
treatment ofarrhythmias. If the antinuclear antibody test is positive
and thepatient is mildly anemic, which of the following medications is
shemost likely taking? [i] [i] [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif A. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Digoxin [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif B. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Disopyramide [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif C. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Flecainide [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif D. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Mexiletine [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif E. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Procainamide

stepanida
02-25-2005, 08:44 PM
E. Procainamide

pharmacology
02-27-2005, 08:06 PM
A 67-year-old woman is brought to the emergency department
withcomplaints of persistent fever, malaise, and the recent appearance
of amalar "butterfly" rash on the face, as well as numerous oral
ulcers.The patient states that she is taking one medication for
treatment ofarrhythmias. If the antinuclear antibody test is positive
and thepatient is mildly anemic, which of the following medications is
shemost likely taking? [i] [i] [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif A. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Digoxin [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif B. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Disopyramide [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif C. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Flecainide [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif D. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Mexiletine [i]http://iuhs-isa.org/Pharmacology/Cardio/36_files/item_files/spacer.gif E. file:///C:/Documents%20and%20Settings/craig.CRAIG-WPW5HN4US/Desktop/Questions/Pharmacology/Cardio/36_files/item_files/spacer%281%29.gif Procainamide

Yes, very good step

The correct answer is E.
The patient is presenting with signs and symptoms of drug-induced
lupus. This complication is associated with procainamide and other
agents, including hydralazine, chlorpromazine, isoniazid, methyldopa,
and quinidine. Procainamide is a class IA agent, similar in action to
quinidine, and is indicated for the treatment of ventricular
arrhythmias. This agent is has also been associated with
agranulocytosis, bone marrow depression, neutropenia, hypoplastic
anemia, and thrombocytopenia. Digoxin (choice A)
is a cardiac glycoside used for congestive heart failure (CHF), atrial
fibrillation, and atrial flutter. Signs and symptoms of digoxin
toxicity include nausea, vomiting, anorexia, appearance of yellow-green
halos in the visual field, and the development of cardiac arrhythmias.
Disopyramide (choice B)
is a class IA agent indicated for the treatment of documented
ventricular arrhythmias. It possesses strong anticholinergic effects
and is associated with the development of atrial tachyarrhythmias,
heart block, and conduction abnormalities.
Flecainide (choice C)
is a class IC agent indicated for the treatment of life-threatening
ventricular arrhythmias. It is associated with paresthesias, ataxia,
flushing, vertigo, tinnitus, depression, and a worsening of cardiac
arrhythmias.
Mexiletine (choice D)
is a class IB agent indicated for the treatment of life-threatening
ventricular arrhythmias. It is associated with the development of
palpitations, chest pain, CHF, edema, arrhythmias, tremor, nervousness,
blurred vision, CNS stimulation, and convulsions.

http://www.drkoop.com/images/ency/fullsize/1868.jpg

Lupus,discoid - view of lesions on the chest: This close-up picture of
theneck clearly shows the typical rounded appearance of discoid lupus.
Thewhitish appearance is caused by scaling. The two dark spots are
biopsysites and are not part of the disease.

http://www.drkoop.com/images/ency/fullsize/2897.jpg

Therash of lupis is round or disk shaped (discoid) and is characterized
byred, raised patches with adherent scales. The skin pores
(follicles)may be plugged, and scarring often occurs in older
lesions.Approximately 90% of individuals with discoid lupus have only
skininvolvement as compared to more generalized involvement in
systemiclupus erythematosis (SLE).

http://www.dental.mu.edu/oralpath/spresent/lupus/img023.jpg







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