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pharmacology
01-22-2005, 10:37 PM
A 16-year-old boy presents to the emergency room after suffering a generalized tonic-clonic seizure. He is presently restless and irritable, and complains of nausea and headache. A careful history reveals that he had been experimenting with cocaine earlier that day. Physical examination is remarkable for a heart rate of 130 and blood pressure of 150/95. Which of the following mechanisms is most likely responsible for the cocaine-induced hypertension?

A. Blocking norepinephrine reuptake
B. Directly stimulating alpha-1 receptors
C. Directly stimulating beta-1 receptors
D. Directly stimulating beta-2 receptors
E. Inducing norepinephrine release
F. Metabolism to a false neurotransmitter

dr_abhi
01-28-2005, 09:23 AM
ans is A it inhibits norepi reuptake

pharmacology
02-10-2005, 11:27 PM
A 16-year-old boy presents to the emergency room after suffering a generalized tonic-clonic seizure. He is presently restless and irritable, and complains of nausea and headache. A careful history reveals that he had been experimenting with cocaine earlier that day. Physical examination is remarkable for a heart rate of 130 and blood pressure of 150/95. Which of the following mechanisms is most likely responsible for the cocaine-induced hypertension?

A. Blocking norepinephrine reuptake
B. Directly stimulating alpha-1 receptors
C. Directly stimulating beta-1 receptors
D. Directly stimulating beta-2 receptors
E. Inducing norepinephrine release
F. Metabolism to a false neurotransmitter

The correct answer is A. Cocaine is a stimulant that causes hypertension and tachycardia by blocking norepinephrine uptake. This leads to an accumulation of norepinephrine in the synapse, causing greater stimulation of postsynaptic receptors. The receptors that mediate the systemic vasoconstriction are alpha-1 adrenergic receptors, and the receptors that mediate the increases in heart rate and inotropic state are beta-1 adrenergic receptors.

Direct stimulation of alpha-1 receptors (choice B) would increase blood pressure, but this is not cocaine's mechanism of action.

Direct stimulation of beta-1 receptors (choice C) could increase blood pressure by increasing inotropic state, but this is not cocaine's mechanism of action.

Direct stimulation of beta-2 receptors (choice D) would cause vasodilation in the skeletal muscle vasculature, leading to a decrease in blood pressure.

Induction of norepinephrine release (choice E) would increase blood pressure, but this is the mechanism of action of amphetamine, not cocaine.

Cocaine is not metabolized to a false neurotransmitter (choice F).

statiastudent347
07-27-2010, 11:22 AM
A i got that 1 , which anti hyperten agent will not work? das the real question

roadhouse
08-13-2010, 10:22 PM
that one is a bit confusing for some reason, stumped

devildoc8404
08-14-2010, 06:14 AM
Is the patient an "addict," or is the patient "experimenting?" There's a difference, and I would think that the age (16) would tend to indicate the latter.

statiastudent347
09-27-2010, 11:13 PM
A for sure cocaine is also the only local anst... that has peripheral sympathetic actions for that reason







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