selenew

06-24-2011, 11:57 PM

I'm a newcomer to the world of Pharmacology and I am hoping you guys would help familiarize with this subject :l

Here are some of the questions I have a hard time of answering. If this is too basic for you, please help me in finding the answers to these problems.

1) A dose of 2000mg of a drug is administered to a patient and the following blood levels result at the indicated times:

Plasma Conc (ug/ml) Time after dose (hr)

100 ..................................2

50 .................................. 4

30 .................................. 6

What is the estimated volume of distribution?

-i know the formula volume distribution = dose/ concentration but how does this apply to the above question?

2) Provide the predicted resulting concentration at the time of measurement

initial plasma conc (ug/ml) = 120 ; t1/2 = 3 ; time after initial conc (hr) 12 ; predicted plasma conc =?

3) the plasma concentration achieved after oral administration of 80mg propranolol is equivalent to IV administratio of 2 mg Propranolol. Explain the difference in the required dosage.

-how do i prove this?

4) Four different drug products containing the same antibiotic were given to 18 volunteer adult males in a 4 way cross over design. the volunteers were fasted 12 hours prior to taking the drug product. Blood samples werecollected up to 72 hours after the administration of the drug. the following are obtained

drug product dose (mg/kg) AUC (ug/ml x hr)

IV sol 4 58

oral sol 20 300

oral tablet 20 230

oral capsule 20 250

determine the following:

a. apparent volume distribution

b. halflife

c. elimination rate constant

d. total body clearance

-can you provide the formulas to be used in these problems?

-i've looked on different pharmacology books but i can't apply the formulas stated in them.

-any comment will be appreciated

-thanks

Here are some of the questions I have a hard time of answering. If this is too basic for you, please help me in finding the answers to these problems.

1) A dose of 2000mg of a drug is administered to a patient and the following blood levels result at the indicated times:

Plasma Conc (ug/ml) Time after dose (hr)

100 ..................................2

50 .................................. 4

30 .................................. 6

What is the estimated volume of distribution?

-i know the formula volume distribution = dose/ concentration but how does this apply to the above question?

2) Provide the predicted resulting concentration at the time of measurement

initial plasma conc (ug/ml) = 120 ; t1/2 = 3 ; time after initial conc (hr) 12 ; predicted plasma conc =?

3) the plasma concentration achieved after oral administration of 80mg propranolol is equivalent to IV administratio of 2 mg Propranolol. Explain the difference in the required dosage.

-how do i prove this?

4) Four different drug products containing the same antibiotic were given to 18 volunteer adult males in a 4 way cross over design. the volunteers were fasted 12 hours prior to taking the drug product. Blood samples werecollected up to 72 hours after the administration of the drug. the following are obtained

drug product dose (mg/kg) AUC (ug/ml x hr)

IV sol 4 58

oral sol 20 300

oral tablet 20 230

oral capsule 20 250

determine the following:

a. apparent volume distribution

b. halflife

c. elimination rate constant

d. total body clearance

-can you provide the formulas to be used in these problems?

-i've looked on different pharmacology books but i can't apply the formulas stated in them.

-any comment will be appreciated

-thanks