View Full Version : why high lipid solubility always accompanied by high protein binding?

04-17-2010, 03:42 AM
hello, it might be a foolish question, but i can't find any books that explain this..if somebody in this forum know why..please tell me ..thx u:)


04-17-2010, 09:12 AM
because if a drug is lipid soluble then it's not soluble in water and the only way it can be soluble in water/blood is if it's bound to a carrier protein, thus they're highly bound to proteins in the blood stream.

04-17-2010, 09:14 PM
RussianJoo: Hi,thx u for the answer RussianJoo :) ...btw, how can the highly drug-protein bound diffuse through the lipid membrane if they are hold by the protein?thx u

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