View Full Version : Pharmacology Question

11-20-2007, 06:39 AM
A 68-year-old man has stable mild exertional angina. He underwent coronary artery bypass graft surgery 2 years ago. His heart rate is 60/min, blood pressure is 120/60mm Hg, and left ventricular function and hemoglobin are normal. He takes maximally tolerated doses of nitrates and β-blockers.
Which of the following medications would decrease the likelihood of a cardiovascular event in this patient?
A. Angiotensin-converting enzyme inhibitors
B. Angiotensin receptor blockers
C. Digoxin
D. Dihydropyridine calcium blockers
E. Calcium channel blockers

12-17-2007, 12:53 AM
If Cardiovascular events meaning MI, I think the answer is A/B, and I go with B cuz of less side effects: Dry cough! My logic is to decrease remodeling of heart, which is decrease demand of O2 on the heart tissue=Decrease MI risk. So I say B.

06-06-2008, 05:42 PM
I go E.
What is the answer?

03-17-2009, 06:49 AM
Go for A

ACEI inhibit remodelling of heart, vasodilating due to inhibition of the vasoconstricter Ang-II plus increase levers of Bradykinin which also is a potent vasod., inhibit aldosterone release, and decrease mortality over time. Do not have much effect on Hr and CO.

ARB are given to p with negative side effects to ACEI like angioedema due to increased bradykinin levels.

01-29-2010, 01:56 AM
I go with A. Ca blocker may not be right, since the heart rate is pretty low already

04-16-2010, 09:25 PM
arent CCBs the drug of choice for exertional angina?

07-24-2010, 01:28 PM
ace inhinitors for sure , final answer , lolol
only thing really proven to decrease mortality in cvs disease
what u got?

02-27-2011, 10:35 PM
I agree with ******. ACE Inhibitors are the treatment of choice. There's no reason to start with an ARB unless they've failed the ACE Inhibitor due to SE's. Also, ARBs are less well-proven in reducing adverse outcomes compared to ACE Inhibitors.

04-26-2011, 02:30 AM
I would go for A

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