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pharmy
03-18-2007, 08:25 AM
Which of the diuretics is most likely to induce encephalopathy in a patient with hepatic cirrhosis?

a> Acetazolamide
b> Mannitol
c> Furosemide
d> Dihydrochlorothiazide
e> Spironolactone
f> Triamterene
g> Amiloride
h> Eplerenone

GFLIP
03-18-2007, 08:33 AM
I'm going with A --- Acetazolamide increases ammonia which accumulates causing encephalopathy.

pharmy
03-22-2007, 06:41 PM
I'm going with A --- Acetazolamide increases ammonia which accumulates causing encephalopathy.


Gflip, Good job!

MDiva
04-15-2007, 10:01 AM
I'm going with A --- Acetazolamide increases ammonia which accumulates causing encephalopathy.

How does this happen?

IMG SURVIVOR
04-15-2007, 12:14 PM
How does this happen?


Acetazolamide inhibits anhidrase carbonic, thi enzyme do this:

H2O + CO2 = H2CO3, and also is a reversible reaction.

Remember that you can go into Metabolic Acidosis with this medication.

If anyone has a more detail explanation please share it.

MDiva
04-16-2007, 07:40 AM
Is it because the protons on NH4+/NH3 are "making up" for the ones not getting back in because we are blocking the H+ plus HCO3- reaction?







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