View Full Version : bromocriptine

08-24-2006, 11:07 PM
What is the difference between bromocritine and selegline in there MOA for parkinsons?

08-05-2008, 09:53 PM
Bromocriptine is a D2 agonist --> dopamimetic
Selegeline is a MAO-B inhibitor --> blocks peripheral degradation of dopamine (and if you give L-dopa along with Selegeline, it decreases peripheral degradation/conversion of L-dopa)

12-15-2008, 10:48 AM
Parkinson = degeneration of nigrostrial dopamine pathway= decrease DA/increase Ach input to striatum, therefore the goal of Parkinson treatment =decrease the overall ration of DA/Ach, in order to do so DA must increase and Ach must decrease.
(Nigrostrial system is involved in voluntary movements of muscle= consists of sub.nigra basal ganglia {caudate putamen and globus pallidus}, subthalamus and thalamus. DA is the primary NT that connects sub.nigra to basal ganglia)

1-Agonize dopamine receptor = Bromocriptine (also used to treat hyperprolactinema and acromegaly)
2-Prevent dopamine breakdown in the CNS = Selegiline (selective MAO type B inhibitior), with this pxt. can consume chesese because it doesn't effect MAO type A. This treatment is used INITIALLY with L-dopa so that dopamine is able to remain within the CNS.
Adverse effect: Insominia because its metabolized to amphetamine therefore pxt. must take the drug in the morning.

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