Immunology Chat transript

[Anonymous]

17:59:51 Step_1 enters this room

17:59:52 >[Step_1] Welcome to our chat. Please obey the net etiquette while chatting: try to be pleasant and polite.

18:00:07 [Step_1] hi everyone!

18:00:32 Lorena enters this room

18:00:38 artery enters this room

18:01:03 [Lorena] hello everybody

18:01:04 cyberdoc enters this room

18:01:13 homeobox enters this room

18:01:18 [Step_1] hi lorena

18:01:30 [Lorena]

18:01:34 [docj] hi, immuno chat?

18:01:51 [Lorena] i am glad to see more people showed up this time

18:01:59 [Step_1] yes, immuno it is

18:02:02 [Lorena] hello homeobox!

18:02:17 [homeobox] hi lorena!

18:02:30 [sanya] Hello everyone!

18:02:37 [artery] so is this where immuno chat here?

18:02:42 [Step_1] its good to be here this time. i think we can all pass this thing if we work together

18:02:43 [Lorena] i went to the <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10000052&type=4 &subid=0>Kaplan</a> center today for the diagnostic test

18:02:54 [cyberdoc] hi, glad to see you guys here

18:03:22 [Step_1] oh, a couple of housekeeping rules, dont right kap lan cause it will put up a link instead

18:03:33 tingler enters this room

18:03:35 [Lorena] thats what i see

18:04:07 [Lorena] ok ...start eith the questions

18:04:08 [homeobox] Hi, all, you can click right button to adjust your font color.

18:04:09 [Step_1] anyone who has black or another dark color, you can choose your color by clicking the rainbow on the right side of "send"

18:04:37 [Lorena] IL involved in Immunoglobulin switching?

18:05:05 [Step_1] CD40

18:05:14 [sanya] Il4

18:05:27 [homeobox] IL4 ?

18:05:30 [docj] CD 40 ligand on t-cell and cd 40 on b-cell

18:05:35 [tingler] IL4

18:05:36 [Lorena] i think sanya is correct and homebox

18:05:45 [Lorena] yes, thats it

18:05:46 [Step_1] IL 4,,5,6,10

18:05:55 [suzzy] lL4

18:05:57 alreadylate enters this room

18:06:15 [docj] oops ... sorry

18:06:35 [alreadylate] hi everyone

18:06:47 [Lorena] welcome alreadylate

18:06:56 [Step_1] hi alreadylate...very appropriate name

18:07:04 [alreadylate] sorry

18:07:11 [Step_1] just kidding

18:07:19 [artery] def if dexay accelerating factor?

18:07:50 [Lorena] what kind of Immunoglobulin IgA is present in saliva? and which one in serum?

18:07:51 [homeobox] PNH

18:07:57 [alreadylate] i didn't get the q

18:08:07 [alreadylate] IgA

18:08:12 [Lorena] dexay accelerating factor???

18:08:24 [Lorena] it is IGa but 1 or 2?

18:08:34 [homeobox] secretion form in salia, non secretion form in serum

18:08:34 [artery] def of decay accelerating factor sorry

18:09:06 [artery] pnh is correct

18:09:39 [alreadylate] wts a decay accelerating factor?

18:09:54 [alreadylate] haven't read about it

18:09:57 [Lorena] never heard of that

18:10:05 [Lorena] :-S

18:10:18 [Step_1] please explain already late

18:10:19 [sanya] it is there in levinson,complement chapter.

18:10:20 [cyberdoc] what happens deficiency of c1,c2 or c4

18:10:31 [suzzy] mee too.

18:10:47 [alreadylate] C2.....nisseria infections

18:10:52 [Lorena] poor clearance of immunocomplexes

18:11:08 [Step_1] calssical pathway

18:11:08 [cyberdoc] what is job's syndrome

18:11:10 [homeobox] a factor involve in complement degradation

18:11:13 [sanya] defective opsonization with ci c2 or c4

18:11:27 [homeobox] job, hyper IgE

18:11:36 [tingler] Role of Fas ligand

18:11:43 [artery] it is in first aid

18:11:45 [sanya] Job's syndrome hyper IgE

18:11:48 [alreadylate] C4 dec in heriditary angioedema deff

18:11:52 [homeobox] apopotsis

18:11:59 [cyberdoc] fas ligand induces apoptosis

18:12:16 [Lorena] i agree with cyberdoc

18:12:20 [suzzy] hereditary agioedema

18:12:30 [Step_1]>[alreadylate] C1 is hereditary angiodema, C5-9 is neisseria

18:12:52 [Lorena] defects in C1 estersase inhibitor

18:12:52 psauls7211 enters this room

18:12:59 [homeobox] what happens deficiency of c1,c2 or c4--prone to bacterial infection

18:13:00 [sanya] def of C1 esterase inhibitor

18:13:01 [Step_1] right?

18:13:17 [cyberdoc] yes, job high Ige, also decreased neurophil chemotaix

18:13:20 [alreadylate] herditary angioedema

18:13:21 shawn enters this room

18:13:43 [homeobox] What is cold abscess?

18:14:09 [shawn] tuberculosis

18:14:21 [Step_1] yes my guess is C1 is hereditary angioedema

18:14:21 [shawn] causing abcess

18:14:25 [sanya] seen in CGD due to infections with Staph

18:14:28 [Lorena] granuloma???

18:14:31 shawn exits from this room

18:14:32 [cyberdoc] c1,2,def.presents with lupus -like

18:14:33 [alreadylate] cold avcess seen when there is no chemotaxis of inflammatory cells to the bacterial invasion site

18:14:47 aj enters this room

18:14:49 shawn enters this room

18:14:50 [tingler] Cell surface markers required for lysis of Igg coated target cells

18:15:03 [alreadylate] CD 16

18:15:09 [homeobox] So which cells are present in cold abscess?

18:15:12 [cyberdoc] c3b, lgG for lysis?

18:15:20 [Step_1] negative NBT test

18:15:25 [shawn] it is also called collor stud abcess in the nect but for different reasons .

18:15:36 [tingler] right CD16

18:15:52 [Lorena] tell us homeobox

18:16:01 [Lorena] about the cold abcess

18:16:16 shawn exits from this room

18:16:22 [homeobox] I guess inly necrotic cells.

18:16:29 [alreadylate] i think there is a diff in cold abcess & CGD

18:16:51 shawn enters this room

18:16:53 [Step_1] what is deficient in CGD?

18:17:03 [alreadylate] in cold abcess there is a defect in chemotaxis while in CGD there is defective killing of bacteria

18:17:12 [homeobox] NADPH oxidase

18:17:18 [alreadylate] in CGD NADPH oxidase is deff

18:17:21 shawn exits from this room

18:17:26 [homeobox] excellent alreadylaet!!

18:17:27 [Lorena] NADPH oxidase

18:17:29 [sanya] subunit of NADPH

18:17:32 [suzzy] nadph oxidase

18:17:41 [Step_1]>[alreadylate] so then cold abscess is the same as chediak higashi?

18:18:02 [alreadylate] child with partial albinism & recuurent infections, Dx?

18:18:06 [Step_1] yes nadph oxidase is deficient in CGD and has negative NBT test

18:18:12 [Lorena] antobodies in Sjogren syndrome?

18:18:27 [alreadylate] anti SSB

18:18:30 [cyberdoc] CHDEIAK-HIGASHI SYN FOR ALBINO KID

18:18:49 [alreadylate] u r right cyberdoc

18:19:01 [sanya] defect in nuetrophil chemotaxis

18:19:04 [Lorena] correct

18:19:13 [tingler] A 2-year-old child has had three episodes of pneumonia and two episodes of otitis media. All the infections were demonstrated to be pneumococcal. Which disorders ?

18:19:19 [alreadylate] in chedak higashi there is chemotaxis defect as well impaired fusion with lysosomes

18:19:29 [Step_1] C5a

18:19:55 [alreadylate] Bruton's X linked hypogammaglobimnemia or

18:20:00 [cyberdoc] THE DEFECT OF CHS IS MICROTUBLE FUCNTION

18:20:08 [homeobox] agree

18:20:11 [alreadylate] transient hypogammaglobinemia

18:20:19 [sanya] chemotactic factor is C5a

18:20:49 [alreadylate] tingler am i right?

18:21:03 shawn enters this room

18:21:42 [Lorena] tell us tingler

18:21:44 [tingler] right. B cell deficiency

18:21:48 [alreadylate] graft versus host dis , wt type of hypersensitivty?

18:21:48 [cyberdoc] ANYTHING ABOUT LEUKOCYTE ADHESION DEF SYN?

18:22:05 shawn exits from this room

18:22:16 [docj] def CD18

18:22:17 shawn enters this room

18:22:20 [Lorena] defect in CD18 beta chain

18:22:35 [Step_1] absent thymic shadow on x ***, low t cells, cardiac malformation, hypothyrodism, fungal infections. diagnosis?

18:22:50 [alreadylate] yes there r two types, LAD 1 & @, ususally characterized by non separation of umbilical cord after birth

18:22:50 [sanya] Di Georges

18:23:00 [Lorena] di george

18:23:00 [suzzy] right

18:23:00 [cyberdoc] DIGEROGE

18:23:03 [tingler] The most common serologic test used for the detection of HLA antigens on lymphocytes

18:23:06 [Lorena]

18:23:24 [Step_1] type 4 for graft vs host

18:23:24 [cyberdoc] RIGHT ALREADYLATE, WHAT ANOTHER ONE

18:23:25 shawn exits from this room

18:23:42 [alreadylate] u r right step 1

18:23:49 [Step_1] yes the correct answer is digeorges....good job!

18:24:18 [cyberdoc] WHAT IS CD18, I MISSED IT, PLS

18:24:28 [Lorena] classical traide of wiscott aldrich syndrome?

18:24:29 [alreadylate] tingler wts the test for HLA?

18:24:48 [tingler] right . Delayed hypersensiivity

18:24:51 [alreadylate] thrombocytpenia, eczema & immunodeff for WA syd

18:25:02 [Lorena] defect in CD18 leads to leukocyte adhesion deficiency

18:25:10 [tingler] complement-dependent cytotoxicity test

18:25:12 [cyberdoc] PREDISPOSED TO LYMPHOMA TOO

18:25:13 [docj] right

18:25:23 [tingler] ataxia telengectesia

18:25:33 [tingler] right already late

18:25:42 [Lorena] yes, you guys are right

18:26:07 [Step_1] what is this marker for...CD3? CD21? CD 30?

18:26:21 [Step_1] 3 separate things

18:26:29 [tingler] sorrry wiskott aldrich

18:26:37 shawn enters this room

18:26:38 [alreadylate] variable deff of B cells & T lypho, usually Ig A ia absent, recurrent siupulmonary infec, ataxia & telengectasia, esp under sclera, blue sclera

18:26:48 shawn exits from this room

18:26:55 [Lorena] CD3 signal transduction (limp T)

18:26:58 nimta49 enters this room

18:27:08 [sanya] CD3 signal transduction present close to TCR on Tcell

18:27:16 jinyan enters this room

18:27:17 [Lorena] CD21 is on B cells

18:27:26 [alreadylate] CD 3 is sigal transduction from TCR receptor

18:27:41 [sanya] CD21 EB virus binds to it

18:27:58 [alreadylate] CD21 is complemet receprot on B cells, also where EB virus attacks

18:28:11 [alreadylate] don't know about CD 30?

18:28:18 [Lorena] i i dont know about CD30

18:28:27 [artery] il12 def?

18:28:43 [suzzy] CD 30 RS cell of hodgkins

18:28:45 [Step_1] yes, generally CD3 is present on all T cells so it can be used as a marker for T cells. CD21 is marker for EBV. CD30 is marker for reed sternberg

18:29:04 [homeobox] CD30-Lymphocyte activation antigen, related to tumor necrosis factor

18:29:06 [alreadylate] IL 12 is reposn for formation TH1 from Th0

18:29:09 [sanya] IL12 activates helper T cells, I guess

18:29:10 [Lorena] IL12 activates NK, induces TH0 to TH1

18:29:28 doc27 enters this room

18:29:40 [tingler] CD40 Ligand (CD154) is expressed by

18:29:44 [cyberdoc] BOOD TRANSFUSION CONTRAINDICATED FOR WHAT PT WITH IMMNU DISEASE?

18:30:06 [sanya] Ig A def

18:30:18 [suzzy] Ig a

18:30:22 [Lorena] IgA def

18:30:26 [homeobox] CD40 ligand- B cells

18:30:40 [alreadylate] CD 40 expressed by both T & B cells, usually involved in class switching

18:30:40 [cyberdoc] ALL CORRECT

18:30:42 shawn enters this room

18:31:02 [Step_1] which immunoglobulin crosses placenta?

18:31:15 [alreadylate] IgG crosses placenta

18:31:16 [Lorena] igG

18:31:16 [tingler] Avtivated T cells

18:31:16 [docj] ig G

18:31:18 [cyberdoc] LGG

18:31:23 [shawn] igg

18:31:26 [homeobox] IgG

18:31:28 [tingler] CD40 ligand (CD154) is expressed on the surface of the CD4+ T cell as a consequence of the activation that follows the binding of peptide + MHC class II to the TCR.

18:31:30 [suzzy] IgG

18:31:34 [Lorena] CD40is on B cells

18:31:39 [nimta49] igG

18:31:39 [Lorena] D40 ligand is on T cells

18:31:54 shawn exits from this room

18:32:02 [homeobox] Thanks for coeection, tingler

18:32:03 [tingler] IgM

18:32:23 [Step_1] thats right its IgG. what happens if you find IgM in a newborn infant, what does this mean and where did it come from mom or baby?

18:32:28 [tingler] IgG

18:32:44 [homeobox] It comes form baby.

18:32:46 [Lorena] baby i guess

18:32:50 [cyberdoc] BABY INFECTION

18:32:57 [homeobox] mean baby has infection

18:32:57 [alreadylate] IgM is the first antibody produced by the infant & is the sign of placental infection

18:33:01 [Lorena] it is too big to cross placenta

18:33:11 [sanya] Ig M is the 1st Ig to be formed in the NB

18:33:19 [suzzy] congenital inf.

18:33:36 [Step_1] thats right cyberdoc, only IgG crosses, so IgM would indicate baby infection where baby has produced IgM

18:34:09 [tingler] The ability of a single B cell to express both IgM and IgD molecules on its surface at the same time is made possible by

18:34:24 [alreadylate] alternative splicing

18:34:27 ninianina1564 enters this room

18:34:32 [cyberdoc] WHICH IL STIMULATES LgA? lgM?

18:34:50 [tingler] good

18:35:02 [homeobox] agree with alreadlate

18:35:24 [docj] il 5 for ig A

18:35:34 [alreadylate] Ig A stimulated by IL 5

18:35:39 [tingler] looks like you are studying hard ? already late

18:35:44 [suzzy] Is It IL2

18:36:10 [alreadylate] just trying tingler

18:36:14 [Lorena] Il 5

18:36:17 [sanya] No Il2 activates cytotoxic tcells

18:36:30 psauls7211 enters this room

18:36:46 [homeobox] IgM-IL4

18:36:53 [cyberdoc] il5 for lgA, il4 for lgE. sorry not lgM

18:37:18 [alreadylate] blood given to immunocomp child, wt sort of hypersensitivity reaction?

18:37:25 [cyberdoc] u guys wanna go over all the functions of il?

18:37:37 [tingler] type 2

18:37:37 [Lorena] type II

18:37:44 [Lorena] citotoxyc

18:37:48 [tingler] cytotoxic

18:37:49 [Step_1] if you see V2,J3,C and V2,D9,J3,C which one is light chain and which one is heavy?

18:37:52 [homeobox] type4

18:37:58 [suzzy] Type 2

18:38:05 [alreadylate] no tingler its graft versus host reaction & will be type 4

18:38:14 [artery] what are the mhc's?

18:38:23 [cyberdoc] type 4

18:38:32 [homeobox] agree with alreadylate.

18:38:44 [Step_1] i think its type 2 coz no tcells in immuno compromised?

18:38:47 [tingler] hyperacute graft rejection. what type?

18:38:48 [sanya] vdjc is heavy chain

18:38:49 [alreadylate] graves dis wt type of hypersens?

18:39:03 [homeobox] V2,J3,C--light chain and V2,D9,J3--heavy chain

18:39:06 [cyberdoc] 2

18:39:08 [Lorena] type II also

18:39:15 [suzzy] Type2

18:39:25 [docj] 2

18:39:30 [alreadylate] hyperacute is type 2

18:39:31 [Step_1] yes sonya,and homeobox. the heavy chain has the D in it. good job!

18:39:35 [homeobox] can u explain why it is type?

18:39:43 [homeobox] I eman type2?

18:40:23 [alreadylate] hyperacute is type 2 b/cos the graft is immediately attacked by preformed antibodies

18:40:32 [Lorena] it is caused by antibody directed against the surface of a cell or pathogen

18:40:59 [Step_1] i didn't come up with the question, but if immunocompromised means no or low tcells. hyperacute rejection is type 2 so it is probably that one

18:41:08 [suzzy] against cell

18:41:22 [homeobox] But for that GVH, there is no rejection.

18:41:29 [tingler] can u explain how blood given to immunocomp child is type 4 and why not type 2

18:41:35 [Lorena] in tranfussion :antibody agains red cells

18:42:25 [homeobox] in GVHD, hgraft lymphocyte attack host tissue.

18:42:29 [tingler] isn't it a transfusion reaction

18:42:45 [Lorena] it is also the cells involved ...antibodies :type 2. T cells: type 4

18:42:53 [homeobox] it is like a cytotoxicity.

18:43:04 [alreadylate] b/cos its kust like u implant bone marrow in a leukemic pt, but here u r transfusing the person with B & T cells in the blood which recognize the host cells as non self & attack them

18:43:11 [Lorena] exactly, thats why it is called citotoxic

18:43:34 [homeobox] So what is answer to this Q? Type 2 or 4 or both?

18:43:51 [Lorena] type 2

18:44:03 [alreadylate] graft versus host is type 4

18:44:21 [cyberdoc] agree 4

18:44:53 [alreadylate] diff between mast cells & bsophils?

18:44:59 [tingler] Iam still confused

18:45:14 [Step_1] one in blood and other in tissues.

18:45:28 [docj] which one?

18:45:31 [homeobox] Tingler, it is CTL which act to kill the cell, so it is type4

18:45:50 [cyberdoc] it is the t cells from immunocompetent cell attack immunocopmromise host the cells are effectors. so type 4

18:45:58 [tingler] got it

18:46:17 [alreadylate] see tingler, b/cos in an immunocomp person the bodies t cells r non functional so giving them blood would not ellicit a normal transfusion reaction

18:46:19 [Step_1] how will the immunocompromised child have the tcells to mediate the reaction?

18:46:20 [tingler] thanks guys. I am mildly demented

18:46:47 [homeobox] DOn't be modest,tingler.

18:47:23 [homeobox] mast cell-cirlaer type, basophils-tissue type

18:47:27 [Lorena] mast cells are present in all tissues, mostly in mucosal surfaces

18:47:28 [alreadylate] wts the diff between basophils & mast cells

18:47:47 [alreadylate] right homeobox

18:47:47 [cyberdoc] baso is blood, mast in tisstue

18:47:48 [Step_1]>[alreadylate] one is in blood and other in tissue

18:48:06 [tingler] when basophillsfrom blood stream to the tissues they are called mast cells

18:48:17 [Lorena] basophils are teh circulating granulocytes

18:48:21 [tingler] move from

18:48:36 [alreadylate] correct everyone

18:49:00 [sanya] Mismatched transfusion -- results in which type of hypersensitivity reaction

18:49:11 [alreadylate] deff in beta 2 microglubin?

18:49:17 [homeobox] TYpe II preofrmaed AB

18:49:19 [alreadylate] type 2

18:49:21 [Lorena] type 2

18:49:25 [suzzy] type2

18:49:32 [Step_1] IgG, IgM, IgG, etc. what is difference...isotype, allotype or idiotype?

18:49:38 [sanya] yes!

18:49:55 [Lorena] isotype

18:50:02 [homeobox] alreaylate I don't understand your q.

18:50:03 [sanya] they are dif isotypes

18:50:28 [alreadylate] type 2 microglobin is assoc with class 1 MHC molecules

18:50:45 [Step_1] yes sanya, very good! what about diffence for IgG1, 2, 3, and 4?

18:50:50 [homeobox] ok, thanks

18:51:06 [alreadylate] thats isotype too

18:51:06 [homeobox] idiotype

18:51:08 [sanya] isotypes are due to dif chains in the constant regions of heavy and light chains

18:51:33 [Lorena] allotypes for IgG1, IgG2, etc

18:51:33 [tingler] tyep 3 SLE

18:51:35 [Step_1] sorry lorena, you got it right too...good job!

18:51:47 [cyberdoc] pair please. rolling, sticking, diapedesis with PECAM, SELETIN, AND ICAM?

18:51:53 [sanya] Ig1234 are also diff isotypes

18:52:13 [Step_1] IgG1,2,3,4 are also different isotypes...trick question, but important

18:52:28 [Lorena] oh...thanks!

18:52:42 [cyberdoc] BETA 2 DEFI, SO NO FUNCITIONAL MHCI

18:52:46 [Step_1] only signifcance of allotypes is paternity testing

18:52:50 [alreadylate] ICAM is diapedsis

18:53:04 [Step_1] and idiotypes refer to the variable regions

18:53:16 [alreadylate] sticking must be PECAM

18:53:26 [Lorena] thank you step 1 for the explanation

18:53:48 [tingler] gotta go. All the best everybody.

18:53:50 [Step_1] no problem

18:53:53 [Lorena] good questions cyber doc

18:54:01 [homeobox] sticking-ICAM

18:54:07 [Step_1] bye tingler. thanks for the help

18:54:22 [alreadylate] bye tingler

18:54:24 [cyberdoc] THNKS, RIGHT, Rolling-selection loose; sticking-ICAM, DIAPEDESIS-PECAM

18:54:27 [Lorena] have a nice weekend tingler

18:54:30 [homeobox] bye tinlger.

18:54:39 [Step_1] maybe we should decide on next weeks topic while everyone is still here?

18:54:47 [Lorena] yes, good idea

18:54:48 [homeobox] Great Q. cyberDoc

18:54:58 [Lorena] what about cardiovascular pathology?

18:55:00 [artery] bye tingler

18:55:17 [alreadylate] yes that sounds goos

18:55:20 [homeobox] may be physio together.

18:55:28 [alreadylate] i mean cardiovascular sounds good

18:55:37 [Step_1] ok, we'll do pathology in general, but concentrate on cardio

18:55:41 [cyberdoc] physio sounds good to me.

18:55:46 [alreadylate] ok

18:55:47 [Lorena] yes, physio and patho ..cardiovascular

18:56:01 [homeobox] ok

18:56:20 [cyberdoc] good, maybe we should let more ppls know so we will have more ppl come ine

18:56:20 [artery] how about genetics?

18:56:42 [homeobox] How about cardio pathphsio, epharmo, embryo all together?

18:57:07 [sanya] yeah I would be happy if we could discuss genetics sometime

18:57:14 [Lorena] i prefer cardiovascular path, physio, etc intead of genetics

18:57:18 [alreadylate] thats a little too uch, we won't be able to do all that

18:57:29 [artery] ok let us do that next week

18:58:00 [Lorena] so cardiovascular Patho and physio it is!

18:58:02 [artery] let us do genetics later

18:58:09 [Lorena] is it ok?

18:58:17 [alreadylate] ok lorena

18:58:36 [alreadylate] ok guys a have one q

18:58:42 [Step_1] and then genetics the following week? is that right? if so i agree. if not please explain

18:58:43 [alreadylate] n anyone clear that for me?

18:59:11 [cyberdoc] ok

18:59:11 [alreadylate] i know wt ataxia telengactasia is from immuno discussion

18:59:16 [Lorena] yes, thats it i guess step 1

18:59:32 [Step_1] thanks lorena

18:59:34 [sanya] Fine with me!

18:59:51 [artery] me too

18:59:56 [Lorena] what book are you going to use for genetics?

18:59:58 [alreadylate] but i was reading mol biology & it said that ataxia telengactasia is due to DNA repar defect

19:00:16 [Lorena] to reserve it in the library with time in advance

19:00:18 [alreadylate] & is due to X rays or something, does anyone know anything about that?

19:00:25 [suzzy] corect

19:00:37 [Lorena] yes alreadylate

19:00:52 [sanya] I have just read <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10000052&type=4 &subid=0>Kaplan</a>

19:00:57 [alreadylate] ok so its the same ataxia telengactasia?

19:01:01 [Step_1] i use kap lan notes and first aid. what about others

19:01:05 [sanya] Oops!

19:01:20 [Lorena] it is the same ataxia telangiectasia

19:01:31 [alreadylate] i read <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10000052&type=4 &subid=0>Kaplan</a> for genetics too & think its pretty good

19:01:44 [Lorena] but that defect in reapair of DNA affects T cells

19:01:45 [sanya] yes step1 I did the same

19:01:49 [alreadylate] wts happening here?

19:01:56 [Step_1] you can write the word KAP-LAN

19:02:03 [alreadylate] ok thanks lorena

19:02:12 [artery] genetics nms too much only for reference

19:02:20 [alreadylate] ok

19:02:33 [Lorena] ok, i'll study there then ...i 'll buy the <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10000052&type=4 &subid=0>Kaplan</a> notes

19:02:40 [Lorena] opps, i did it again!

19:02:48 [Lorena] ka-plan notes!

19:03:10 [alreadylate] hey can anyone give me any tips on doing biochem, seems i can't remeber all those cycles & the inducing & inhibiting factors

19:03:19 [Step_1] you don't need to buy them if u have something else. its the same material just presented differently

19:03:33 [Lorena] ok..some more questions to remember the HLA DR and diseases

19:04:10 [Lorena] yes, you are right step 1 ...they are pretty expensive

19:04:14 [homeobox] ataxia telangiectasia is causeed by defect in DNA repair

19:04:36 [cyberdoc] got to go. see u guys next time

19:04:40 [homeobox] I think it is the same ataxia telangiectasia you rread in immuno note

19:04:47 [suzzy] agree with you

19:04:55 [homeobox] see u.

19:04:55 [artery] biochem from <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10000052&type=4 &subid=0>Kaplan</a> notes

19:05:01 [Lorena] HLA-DR2 related with what diseases

19:05:12 [homeobox] just type kap

19:05:12 [alreadylate] thanks everone for the help

19:05:22 [alreadylate] Diabetes Mellitus

19:05:38 [alreadylate] ok guys i'll say bye now

19:05:46 [homeobox] No, that is for DR3,DR4

19:05:47 [alreadylate] see u next week

19:05:48 [Step_1]>[alreadylate] for biochem, just concentrate on biggies like rate-limiting steps, etc

19:05:56 [Lorena] ok, seyou next week!!

19:05:59 [homeobox] buy, alreay late.

19:06:02 [alreadylate] thanks step 1

19:06:11 [Lorena] study hard and bring more good questions!

19:06:19 [alreadylate] i'm trying but its still very diff

19:06:32 [alreadylate] bye everyone

19:06:35 [Step_1] ok alreadylate. see you next week. dont forget to try to answer questions during the week in the step 1 forum

19:06:40 [Lorena] you are doing pretty good so far

19:06:40 [homeobox] bye.

19:06:57 [Lorena] see you next week homeobox!!

19:06:59 [artery] where did you guys read immuno from?

19:07:23 [homeobox] kap

19:07:33 [Lorena] <a target=new href=http://click.linksynergy.com/fs-bin/click?id=c97WUMRO5hY&offerid=47491.10001429&type=3 &subid=0>QBank</a>, and princeton review

19:07:34 [Step_1] first aid isn't very good for immuno, so i used kap

19:07:55 [sanya] I read from Kap and LEVINSON

19:08:01 [Lorena] i used Q----bank and PR

19:08:01 [homeobox] Ok, more qs please

19:08:02 [artery] how about jawets?

19:08:31 [Step_1] i think its a little detailed, but it will work

19:08:33 [homeobox] It is good also, more detailed, good graphs.

19:09:06 suzzy exits from this room

19:09:18 [sanya] Yeah that's what i read "Javetz and levinson"

19:09:31 [artery] so cvs physio and patho from kap also or brs?

19:09:47 suzzy enters this room

19:10:27 [sanya] Are we done with the immuno discussion?

19:10:33 [Lorena] i still have questions

19:10:49 [Step_1] the path from kap that i use is from goljan, so i'm not sure its the same. but i'm sure its similar

19:10:54 [Lorena] HLA DR2 and diseases?

19:11:03 [homeobox] pls post more Q

19:11:48 [Lorena] HLADR3 and diseases, HLA DR4 and HLA DR5... name the diseases related with them

19:11:56 [homeobox] DR2-MS

19:12:09 [Lorena] yes

19:12:25 [homeobox] DR3--diabetics

19:12:36 [sanya] HLA DR4 Rheumatoid Arthritis

19:12:42 [homeobox] yes

19:12:42 [Lorena] you are right

19:12:49 [Lorena] both are right

19:13:09 [Step_1] HLA B27?

19:13:21 [Lorena] anchilosys spondilitys

19:13:22 [homeobox] How about B8?

19:13:29 [Lorena] reiter's syndrome

19:13:38 [sanya] Ankylosing spondylitis, Reiters

19:13:41 [homeobox] B27-ankylosing spondylitis

19:13:50 [Step_1] yes correct, very good

19:14:05 [Lorena] HLA DR5?

19:14:07 [homeobox] B8-myasthenia gravis

19:14:26 [Lorena] thank you i didnt know that one!

19:14:49 [homeobox] u r welcome. Moew Q pls

19:15:02 [Lorena] HLA DR5 - pernicious anemia

19:15:22 [Step_1] HLA-A3?

19:15:36 [sanya] Hemochromatosis

19:15:36 [homeobox] hemochromatosis

19:15:36 [Lorena] i'll give you what i have about the HLA DR

19:15:59 [Lorena] HLA DR@: multiple sclerosis, Goodpasture, Narcolepsy, Hay fever

19:16:09 [Lorena] sorry it was HLADR2

19:16:19 [Step_1] actually thats a tough one, HLA A3 is hemochromatosis, but not HY so dont worry about it

19:16:47 [Lorena] HLA DR3 DM1, Sjogren, chronic hepatitis and celiac spruer too

19:17:22 [Lorena] HLA DR4 DM too, Reotmathoid arthritis, pemphigus vulgaris

19:18:26 [Step_1] good stuff. thanks lorena

19:18:47 [Lorena] my pleasure

19:19:05 [Step_1] what about HLA A, B, C....is that for class 1 or 2 antigens?

19:19:10 [homeobox] Thank u loreana, very good list!

19:19:40 [Lorena] SLE is related with HLA DR2 and 3

19:20:03 [homeobox] Which one below does not arise from myloid stem cells:

19:20:08 [Lorena] they are class II?

19:20:10 [homeobox] A. Eosinophils

19:20:21 [Lorena] 2

19:20:43 [Step_1] HLA A, B, C is assoc with MHC class 1 while HLA DP, DQ, and DR are associa with class 2

19:21:12 [Lorena] opps...

19:21:52 [homeobox] Which one is most imporant in transplantation matching?

19:22:15 [sanya] Class I antigens

19:22:25 [Lorena] class 1

19:23:31 [Step_1] whats the answer?

19:23:35 [homeobox] I think it is MHC class II.

19:24:27 [Step_1] which one assoc with beta 2 microglobulin?

19:24:52 [sanya] class I antigens

19:25:16 [Step_1]>[sanya] yes very good.

19:25:42 [homeobox] class I

19:25:57 [Step_1] what about assoc with CD8? CD 1?

19:26:15 [Step_1] 2 separate questions

19:26:21 [Lorena] class I-cd8

19:26:29 [homeobox] CD8-mhcI,CD4-mhc4

19:26:38 [sanya] CD8 is assc with MHC 1

19:26:52 [homeobox] sorry, i eman CD8-MHCII

19:26:53 [Lorena] CD4-class II

19:27:00 [sanya] CD4 MHC 2

19:27:29 [Step_1] CD8 = MHC 1 and CD4 = MHC2....here is the mneuomonic...

19:27:46 [Lorena] how many HLA class I do we have?

19:28:00 [Step_1] 8x1=8 and 4x2=8 so they must equal 8

19:28:32 [Lorena] thanks

19:29:43 [sanya] Which is the immunogloblin that opsonizes?

19:29:55 [Lorena] igG

19:30:11 [homeobox] IgG

19:30:16 [Step_1] IgG

19:30:25 [sanya] Yes!

19:30:44 [homeobox] what Ab fix complement?

19:30:54 [sanya] Whic is the Ig that opsonizes indirectly

19:31:15 [Lorena] igG and igM activate complement

19:31:15 [sanya] IgM & Ig G

19:31:21 [homeobox] Iyes

19:31:54 [Step_1] which is major IgG in secretions?

19:32:00 [homeobox] Ag opsonize, i haven't head.

19:32:03 [Lorena] igA2

19:32:09 [sanya] Ig A

19:32:40 [Lorena] igA2 is present in secretions , igA1 in serum

19:32:40 [homeobox] What is answer for Ag opsonization?

19:32:56 [Step_1] yes IgA in secretions, so deficiency means sinopulmonary infection.

19:33:46 [Step_1] IgG is opsonin

19:33:48 [sanya] Whic is the Ig that opsonizes indirectly? it is IgM it activates the complement and the C3b opsonizes so that's why indirect

19:34:07 [Lorena] ahh..good one

19:34:36 [homeobox] Thanks,sanya. Good q.

19:34:53 [sanya] you're welcome!

19:35:24 [homeobox] Is the memory cell Bcell or t cell?

19:35:33 [sanya] both

19:36:09 [Step_1] i thought it was B. is it t also?

19:36:32 [Lorena] what is the answer?

19:36:38 [homeobox] yes, it is B cell

19:36:55 [homeobox] What Abs are present in memory cells?

19:37:16 [sanya] IgG

19:37:19 [Lorena] igG

19:37:31 [homeobox] IgG, IgA,IgE

19:37:45 [Step_1] which Ig seen in acute infection (first to appear)?

19:38:13 [Lorena] igM

19:38:17 [homeobox] IgM, then IgG

19:38:42 [Step_1] yes, IgM always appears first

19:38:59 [Lorena] multiple myelona...mostly what type of Ab?

19:39:11 [sanya] Ig G

19:39:29 [sanya] Waldenstroms Ig M

19:39:44 [artery] igm

19:39:56 [homeobox] Rheumatois arthritis,IgG

19:40:32 [Lorena] igG is right for myeloma

19:41:32 [Step_1] which MHC (1 or 2) assoc with exagenous peptides? endogenous?

19:41:43 [Lorena] i have another list for you -diseases and auto antibodies-

19:41:58 [Lorena] MHC 2 with exogenous

19:42:15 [Lorena] MHC 1 with endogenous

19:42:31 [Step_1] yes lorena, mhc 2 is exogenous and 1 is endo. good job

19:42:33 [homeobox] NHC1-edogenous MHC2-exagenous

19:42:36 [Lorena] is that correct??

19:42:38 psauls7211 enters this room

19:42:39 [sanya] I just went to get my immunology book(Kap). Pg 355 it says some of the ag stimulated Bcells & T ceells differentiate in to memory cells which provide the host with long lived memory for the ag.

19:42:40 [artery] i am not sure

19:43:54 [Lorena] SLE- double stranded DNA, anti smith

19:44:03 [homeobox] Thany u for correction, sanya!

19:44:13 [Lorena] Sjogren syndrome: SS-a, SS-B

19:44:31 [Lorena] wegener's granulomatosis c-ANCA

19:44:34 [sanya] No problem!

19:44:45 [Lorena] graves -anti TSH receptor

19:45:00 [Lorena] CREST syndrome-anti centromere

19:45:10 [Step_1] i think that B cells and TH0 (undifferentiated) can produce memory cells, but the TH0 cells must convert to B first. TH1 and 2 are already differentiated and cannot produce memory...i think

19:45:14 [Lorena] drug induced SLE- anti histone

19:46:05 [Lorena] Good pasture -antiglomerular basement membrane

19:46:21 [Lorena] sistemyc sclerosis -anti scl-70

19:46:37 [Lorena] mixed conective tissue disease-anti ribonucleoprotein

19:47:20 [Lorena] so...what is the final answer then? both B AND T cells?

19:47:49 [homeobox] both B and T can form memeory cell.

19:48:11 [Lorena] thank you guys, thanks sanya for going to look for the answer

19:48:35 [sanya] you're welcome!

19:48:50 [homeobox] Tank u for your good list,loreana!

19:49:19 [Step_1] i'm wrong in the above statement, please ignore. sanya is right. thanks sanya

19:49:20 [artery] thank you lorena

19:49:21 [homeobox] Tho may develop into T memory cells.

19:49:46 [Lorena] i do those lists for my self so i have a quick reference

19:49:53 [sanya] Yes its a good list, very important too, thanks Lorena!

19:50:07 [Lorena] you're welcome

19:50:19 [Step_1] i agree, very good stuff lorena

19:51:19 [Step_1] ok everyone, i have to go. thanks for the chat. i'll post the transcipt in the step1 forum

19:51:33 [Lorena] i have to go too

19:51:48 [Lorena] i'll post the announcement for next chat ...same time, right?

19:52:09 [Step_1] yes, sounds good

19:52:19 [artery] good bye every one i will contribute more next time

19:52:27 [Lorena] this time more people came

19:52:40 [sanya] OK bye & Thanks everyone!

19:52:44 [Lorena] have an excellent weekend everybody and study hard for next chat!!

19:53:08 [Lorena] thanks guys, bye

19:53:11 [Step_1] it was great, everyone particpated and i learned alot. hope everyone else feels the same

19:53:19 [Step_1] bye

19:53:20 [homeobox] Bye, thanks everyone.

19:53:20 [sanya] This is my 1st time, I liked this discssion a lot!

19:53:29 [Lorena] yes, it is motivating too