HY 30

Anonymous · #1 (**permalink**) 11-09-2003, 08:39 PM

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An adult lady with NIDDM,on orAl hypoglycaemics,comes with c/o pain left knee.o/e oateoarthrits L knee,was made out,and patient was prescribed ,low dose ibuprofen.it did not give her complete relief. Why should this pt b put on high dose ibuprofen???
a)anti inflammatory dose twice the analgeasic dose
b)the drug is excreted at a fast rate because of renal complication of DM
c)increasing the dose extends the half life of the drug
d)oral hypoglycemics interfere with protein binding of ibuprofen

Anonymous · #2 (**permalink**) 11-10-2003, 02:27 PM

i think the answer is a)anti inflammatory dose twice the analgeasic dose.

NSAIDs are generally known to enhance the activity of oral hypoglycemics, but ibuprofen is the agent known to have the least amount of interference. so i dont think it has to do with oral hypoglcemics.

the half life shouldn't be affected by the dose because it's an independent constant.

Ref: kaplan pharm notes pgs 9, 163

Anonymous · #3 (**permalink**) 11-10-2003, 02:49 PM

D

Any comment?

I think Ibuprofen has the ff. metabolic SE: hyperglycemia; glycosuria; hyperkalemia.

View Poll Results: An adult lady with NIDDM,on orAl hypoglycaemics,comes with c/o pain left knee.o/e oateoarthrits L kn
a)anti inflammatory dose twice the analgeasic dose	1	100.00%
b)the drug is excreted at a fast rate because of renal complication of DM	0	0%
c)increasing the dose extends the half life of the drug	0	0%
d)oral hypoglycemics interfere with protein binding of ibuprofen	0	0%
Voters: 1. You may not vote on this poll

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