20:07:11 [hutals] ok, ready to get started on antimicrobials?

20:07:12 [Lorena] do you want to start now?

20:07:18 [Lorena] yes

20:07:41 [kmonica26] yes

20:08:03 [jwls29] yes

20:08:55 [hutals] i'm trying to find a diagram on net, but cant. anyway, a previous question had pic with most common type pathway of transmission, which is transduction...

20:09:30 [hutals] they asked what was mech of action?

20:09:59 [Lorena] MOA of transduction?

20:10:50 [hutals] yes, sorry, that is what i meant.....the real question had a diagram of it rather than the word, but you had to know what it was and the mech of action of how its transferred

20:11:16 [Lorena] a donor bacteria or male gives ssome genetic material to a recipient -a female bacteria- by a F factor

20:12:12 [hutals] i think this is the one that is transferred from once cell to another via a phage

20:12:26 [Lorena] thats conjugation ...ops

20:12:51 [Lorena] yes, via a phage-the phage is the "transductor"

20:13:11 [hutals] and i remember something about transFormation being F-ree cells

20:14:00 [hutals] i guess that is more of a micro question, but i happen to have it written in this part of my notes

20:14:08 [Lorena] good one

20:14:51 [hutals] the part that got me was that they wanted you to recognize transduction from a pic?? so try to go over those at some point

20:15:07 [Lorena] ok

20:15:14 [jwls29] ty hutals

20:16:23 [Lorena] antibiotics that can cause crystalluria?

20:16:44 [jwls29] sulfonamides

20:17:05 [hutals] ethylene glycol

20:17:15 [Lorena] yes, very good jwls

20:18:20 [hutals] which drugs develop resistance by beta lactamase cleavage of beta lactam ring?

20:19:29 acestep1 enters this room

20:19:39 [hutals] hey ace

20:19:47 [Lorena] hi ace

20:20:03 [hutals] penicillincs and cephalosporins develop resistance in this manner....another previous real question

20:20:09 [jwls29] hi ace

20:20:14 [kmonica26] pencillin, caphalosporins

20:20:16 [Lorena] organisms have developed resistance to penicillins and cephalosporins

20:20:20 [acestep1] hi hutals n lor . how r u guys

20:20:34 [Lorena] hi ace, good and you?

20:20:35 [acestep1] hey jwls

20:20:41 [hutals] good, how bout u?

20:21:00 [acestep1] im good as well

20:21:06 [hutals] how does erythromycin develop resistance? (q bank question)

20:21:33 [kmonica26] methytranferase formation

20:22:06 [acestep1] agree

20:22:25 [hutals] yep, methylation of base in RNA

20:22:49 [Lorena] thanks

20:23:48 [Lorena] drugs that can cause disulfiram reactions?

20:24:10 [jwls29] metronidazole

20:24:32 [acestep1] metronida, chllorpropa, cefoteetan n pefperazone

20:24:33 [hutals] metro

20:24:41 [hutals] cefotetan

20:24:45 [hutals] cefamandole

20:24:48 [acestep1] oops sorry imean cefperazone

20:25:01 [hutals] cefoperazone

20:25:30 [acestep1] i think moxalactam as well

20:25:35 [hutals] chlorpropamide

20:25:38 [Lorena] metronidazole, cefotetan, cefoperazone, cefamandole, moxalactam, ketoconazole .....god job

20:25:59 [hutals] 65 yo female presents with prod cough, fever, lobar pneumonia seen on x-ray. what is the drug of choice? (another q bank question)

20:26:36 [acestep1] pen /eph

20:26:55 [kmonica26] amoxicillin..strep pneumo

20:27:10 [Lorena] she has typical neumonia....penicillins or cephalosporins

20:27:10 [acestep1] imean penicillin s or cephlosporins ( 1st or 2nd gen

20:27:37 [Lorena] agree with ace, 1st or 2th generation

20:27:40 [hutals] this patient most likely has community aquired pneumonia, which is most commonly caused by strep pneumo. despite resistance, penicillin is still the drug of choice for the boards. in real life this is not the case

20:27:43 [jwls29] agree with pcn or cephalo

20:28:12 [acestep1] lol. agree

20:28:18 [hutals] ceph is 2nd choice for boards and #1 for real life

20:28:34 [hutals]

20:28:46 [Lorena] patient with gonorrhea , allergic to penicillins...tx?

20:28:48 [acestep1] . k

20:29:19 [hutals] aztreonam

20:29:36 [acestep1] ideally its ceftriazone but since hes allergic i think erythro?

20:30:05 [jwls29] erythro?

20:30:25 [kmonica26] I think erythro or azithro

20:30:29 [acestep1] erythormycin

20:31:02 [Lorena] yes, erythro, azythro or fluoroquinolones

20:31:30 [acestep1] k

20:31:39 [Lorena] aztreonam probably too but it is only IV

20:31:52 [hutals] this was also a real question given as a young girl who developed UTI and allergic to penicillin. the common factor is that they are both gram neg (gonorrhea and e.coli for UTI). according to kap, a pt with gram neg who is allergic to pens should be given aztreonam to specifically cover gr neg

20:32:45 [Lorena] very good everybody

20:33:23 [acestep1] ic . ididnt know tht hutals

20:33:33 [hutals] azithromycin will cover gr -, but clarith will not cover gonorrhea

20:33:33 [Lorena] what if the patient is pregnant, gonorrhea+ allergy to penicillin?

20:34:18 [kmonica26] azithro is safe

20:34:26 [kmonica26] in preganancy

20:34:48 [hutals] i'm not sure if can give with pregnancy? i know you can give azith with pregnancy, so probably best choice

20:34:56 [acestep1] i still go for erythro

20:35:08 [Lorena] excellent monica

20:35:11 [acestep1] k

20:35:31 [Lorena] and hutals

20:35:31 [kmonica26] thanks

20:36:00 [Lorena] erythromycin too but not in the estolate form because it can cause cholestasis specially dangerous in pregnancy

20:36:28 [acestep1] yes . i forgot abt tht

20:36:31 [Lorena] only erythromycin base or ethylsuccinate

20:36:55 [acestep1] yes. agree

20:37:22 [hutals] what drug most commonly causes C. diff? what treatment?

20:37:51 [kmonica26] clindamycin...treat with vanco or metronidazole oral

20:38:05 [Lorena] clindamycion, lyncomycin, ampicillin but [practically all broad spectrum antibiotics. Tx is metronidazole and vanncomycin is back up

20:38:06 [acestep1] amphicllin

20:38:19 [jwls29] agree

20:38:22 [acestep1] agree with lor

20:38:50 [hutals] C diff caused MC by clindamycin and ampicillin, treat with metro first....vanco if drug resistance

20:39:19 [Lorena] what drug has the infamous side effect of interstitial nephritis?

20:39:37 [jwls29] methicillin

20:39:40 [kmonica26] methicillin

20:39:42 [acestep1] methicillin

20:39:51 [hutals] agree

20:39:58 [acestep1] i think even nsaids n sulfonamides

20:40:00 [Lorena] good!

20:40:37 [kmonica26] which drugs cause phototoxicity?

20:40:40 [hutals] what drug gives "red man syndrome"? what other side effects for this drug?

20:40:41 [Lorena] yes, very probably

20:40:48 [acestep1] sorry sorry we r discussing antibiotics only

20:40:52 [jwls29] tetracycline

20:41:02 [jwls29] vancomycin

20:41:04 [hutals] fluoroquins

20:41:08 [hutals] tetracycline

20:41:15 [kmonica26] vanco for hutals

20:41:15 [jwls29] for red man sdme

20:41:30 [acestep1] i think sulfonamides n tetra n quinolones

20:41:44 [acestep1] tht was for monica

20:41:46 [kmonica26] and yes answer is sulphonaamides, tetracyclies and fluoroq

20:41:55 [Lorena] red man sx is for vanco

20:42:03 [acestep1] for read man - vanco

20:42:35 [Lorena] release of histamine so flushing and hypotension

20:42:48 [hutals] yes, red man is vanco. also ototox, nephrotox, hypersensitivity

20:42:52 [acestep1] agree

20:43:14 [hutals] very good all

20:44:17 [Lorena] tx for syphilis in penicillin allergy?

20:44:23 [hutals] real question had MOA of antifungals (amphotericin or nystatin)?

20:44:57 [acestep1] tetracyclines

20:45:07 [kmonica26] ergosterol interction and makes pores there

20:45:16 [acestep1] oops sorry imean erythro

20:45:25 [jwls29] amphotericin

20:45:27 [Lorena] agree with monica

20:45:30 [acestep1] agree with monica

20:45:50 [hutals] Patients with penicillin allergy can be treated with alternative regimens if they have primary or secondary syphilis. Penicillin is the only effective drug for neurosyphilis; oral desensitization should be accomplished before treatment of penicillin-allergic patients.

20:46:22 [acestep1] ic

20:46:40 [acestep1] from where did u get this

20:46:50 [Lorena] ver good hutals , tetracyclines is also a choice

20:47:10 [hutals] http://www.aafp.org/afp/990415ap/2233.html

20:47:16 [Lorena] it is in k a pl an , at the end of the chapter in q's and asnwers too

20:47:47 [acestep1] k . thnx both of u

20:47:54 [kmonica26] 16-year-old female patient presents with complaints of a

20:48:13 [kmonica26] non-productive cough, low-grade fever, and a headache. The

20:48:23 [Lorena] yw ace

20:48:26 [kmonica26] physician also notes a non-purulent otitis media. She is

20:48:36 [kmonica26] treated with an antibiotic that inhibits the translocation

20:48:49 [kmonica26] of the growing peptide chain along the mRNA. The antibioti

20:49:01 [kmonica26] c the patient was given was

20:49:23 [hutals] erythromycin??

20:49:42 [kmonica26] yep correct

20:49:45 [jwls29] azithromycin?

20:49:48 [acestep1] tetracyclines?

20:49:49 [kmonica26]

20:50:25 [hutals] sounds like atypical pnemonia where the macrolides are the drug of choice

20:50:34 [kmonica26] MOA of Macrolides...basically another way of asking

20:50:46 [acestep1] k

20:50:50 [kmonica26] yes U r absolutely right

20:50:56 [kmonica26] hutals

20:51:15 [hutals] good one because the boards can never seem to ask a straight forward question anymore

20:51:43 [kmonica26] tru

20:51:51 [kmonica26] true

20:51:58 [hutals] what is the DOC for anaerobes?

20:52:17 [jwls29] clindamycin?

20:52:30 [kmonica26] clinda?

20:52:37 [acestep1] metronida?

20:53:12 [Lorena] i would go for metro

20:53:23 [hutals] DOC for anaerobes is Metronidazole....at least according to q bank. clinda i think is #2 (like in alcoholic because of disulfuram reaction )

20:53:59 [acestep1] k . thnx

20:54:13 [Lorena] DOC for ulcerative colitis?

20:54:23 crusher enters this room

20:54:30 [acestep1] i think even k aplan mentions it as doc in metro

20:54:47 [acestep1] sulfasalazine

20:54:54 [Lorena] hi crush

20:54:57 [acestep1] hi crush

20:55:09 [jwls29] sulfasalazine

20:55:15 [jwls29] hi crusher

20:55:18 [kmonica26] agree with jwls

20:55:20 [hutals] Corticosteroids

20:55:37 [acestep1] ic

20:55:49 [crusher] hello all

20:55:53 [acestep1] yes could b

20:56:03 [hutals] hey crush

20:56:17 [Lorena] yes, very good, sulfasalazine when cleaved in the intestin by bacteria , it forms a compound that has local antiinflamatory properties ...also steroids ...very good!

20:56:35 [acestep1] k

20:57:12 [hutals] so sulfasalazine is first choice for UC? thanks

20:57:19 [hutals] didnt know that one

20:58:10 [Lorena] yes, the compound is 5-aminosalicylic acid...sounds antiinflamatory

20:58:29 [hutals] ah yes, that one sounds familiar

20:58:39 [acestep1] yup plus sulfadiazine

20:59:28 [hutals] why can't they just call it ulcerative colitis....azine, or ol, or something easier to remember

20:59:50 [acestep1] lol

21:00:05 [acestep1] ok s/e of aminoglycosides

21:00:07 [Lorena] sulfadiazine+pyrimethamine , what is this combo used for?

21:00:38 [acestep1] toxoplasmosis?

21:00:43 [Lorena] aminoglycosides are nephrotoxic specially if combined with loops, also ototoxic

21:01:08 [acestep1] v gd

21:01:12 [hutals] PCP, salmonella

21:02:00 [acestep1] aslo they r neuromuscular blker so when given with anesthetics they act synergistically

21:02:16 [hutals] what drug can cause hemolysis in G6PD def pts and is also is contraindicated in pregnancy because causes kernicterus from inc unconjugated bilirubin?

21:02:18 [Lorena] yes toxo...good

21:02:28 [acestep1] i thought pcp- cotrimoxazole

21:02:48 [crusher] sulfa drugs .?

21:02:53 [Lorena] sulfadiazines, SMX/TMP

21:03:05 [jwls29] sulfa

21:03:21 [acestep1] agree

21:03:55 [hutals] oops, i got mixed up on lor's question, i thought it said cotrimoxazole which is trimethoprim and sulfamethoxazole

21:04:27 [hutals] anyway, thats the answer to my question, and also happens to be used for PCP and salmonella

21:04:48 [hutals] aka TMP SMX

21:04:53 [hutals] or bactrim

21:05:20 [Lorena] ok, thanks

21:05:27 [acestep1] k. np

21:05:35 [hutals] you all got it right....very good

21:06:04 [Lorena] gray baby syndrome? signs and symptoms , drug that caused?

21:06:06 [hutals] and its a sulfa drug, so thats correct as well

21:06:19 [jwls29] chloramphenicol

21:06:25 [acestep1] chroampheicol

21:06:30 [hutals] is it choramphenicol??

21:06:44 [Lorena] yes

21:06:45 [crusher] cholampenicol

21:06:48 [acestep1] i think it interferes with mitochondria

21:07:37 [Lorena] i just ask for signs and symptoms becausethey will probably just decribe the baby ...and ask what drug caused it

21:07:50 [hutals] i dont remember exact signs, but baby looks a bit gray

21:07:56 [acestep1] agree

21:08:15 [acestep1] i think diff in breathing n cynosis

21:08:16 [Lorena] abdominal distention, vomiting, cyanosis, irregular respiration, hypothermia, CV colapse

21:08:46 [acestep1] so basically all s/s of ischemia

21:09:14 [Lorena] yes, so i think you are right and it interferes with mitochondria-

21:09:33 [acestep1] k

21:09:33 [hutals] i think the cyanosis is the part that produces the "gray" appearance....right?

21:09:58 [Lorena] yes

21:10:20 [acestep1] ya n then in teh end cuz of damage 2 brain n dec atp u have cvs collpase n dec temp

21:10:49 [hutals] ""Gray syndrome" occurs if newborns (especially premature babies) are given chloramphenicol for a bacterial infection. Babies this young do not have the necessary enzymes that allow the liver to metabolize this drug appropriately. The chloramphenicol accumulates in the baby's blood stream, causing

21:10:53 [hutals] hypotension (low blood pressure), cyanosis (blue coloring of lips, nail beds, and skin from lack of oxygen in the blood), and often death."

21:10:54 [acestep1] i think cvs collpase with all od n also resap diff

21:11:35 [acestep1] ok . i thing is it exc by glucoronidation?

21:12:00 [acestep1] n i think mostly was given for h.influenza infections

21:12:13 [crusher] if someone is allergic topenecillin can take cephalosporin?if yes why if not why?

21:12:31 [hutals] good point lorena because they wont be nice enough to say "gray baby" in the question

21:12:31 [kmonica26] But the commonest side effevt of chloramphenicol is dose dependent BOne marrow suppression..I remmeber seeing a question where it was asked

21:12:38 [acestep1] no - cuz bothr b lactams

21:12:56 [Lorena] no, because cross allergy

21:13:21 [jwls29] agree

21:13:27 [crusher] good.no cos both pen n cepholo has samw moa

21:13:29 [Lorena] thanks hutals

21:13:39 [acestep1] yes monica but this bms is much less than bms with other drugs eg czrbemezapine

21:13:45 [hutals] choramphenicol is also cause of aplastic anemia (parvo is other cause of this)

21:14:05 [kmonica26] agree ace

21:14:08 [acestep1] agree

21:14:28 [Lorena] ok

21:15:15 [acestep1] guys im really sleepy

21:16:00 [acestep1] i guess ill read the transcript

21:16:13 [acestep1]

21:16:20 [hutals] ok, good nite ace

21:16:23 [crusher] whts the mechanismof resistance of penicillin

21:16:34 [acestep1] ill see u guys tom . tc

21:16:40 [Lorena] see you tomorrow ace

21:16:46 [kmonica26] beta lactum production

21:16:48 [acestep1] gn all of u

21:16:56 [kmonica26] sory lactamase

21:17:00 [hutals] beta lactamase

21:17:01 [Lorena] good morning to you

21:17:06 [kmonica26] good note ace

21:17:25 [acestep1] i think 3 - b lactamase, dec permeability

21:17:29 [crusher] good nite ace

21:17:39 [acestep1] ya . lol . its morning

21:17:58 [acestep1] gn all of u.

21:18:19 [crusher] b ,lactamase (penicillinase) break lactam ring

21:18:23 [Lorena] agree beta lactamase

21:18:42 [hutals] what is DOC for CMV?

21:19:01 [Lorena] ganciclovyr

21:19:06 [kmonica26] ganciclovir

21:19:10 [crusher] acylovir..

21:19:10 [jwls29] ganciclovir

21:19:24 [crusher] oops yes gan

21:19:52 [hutals] gancyclovir is DOC. acyclovir is the distractor

21:20:23 [Lorena] tx of CMV resistant to ganciclovir?

21:20:44 [crusher] foscarnet

21:20:46 [hutals] foscarnet

21:20:56 [kmonica26] foscaret?

21:21:04 [Lorena] yes

21:21:14 [jwls29] agree

21:21:22 [Lorena] good everybody

21:21:50 [hutals] forcarnet is given to AIDS pts who often get CMV retinitis. what AIDS drug is contraindicated with foscarnet?

21:22:12 [crusher] moa of amantadine

21:22:13 [Lorena] pentamidine

21:22:19 [hutals] and why is it contraindicated?

21:23:02 [hutals] amantadine interferes with attachment, penetration and uncoating of virus

21:23:05 [Lorena] because increases renal toxicity

21:23:37 [kmonica26] and hypocalceamia

21:23:49 [Lorena] agree with hutals , thats why it is only for prophylaxis

21:23:53 [crusher] or uncoating

21:24:22 [crusher] yes good it prevent viral pentration n uncoating

21:24:33 [hutals] yes dont give with pentamidine because renal tox and hypocalcemia

21:25:06 [hutals] AZT should not be given with ganglyclovir because both are neutropenic

21:25:13 [Lorena] jus to remember , mention the anti parkinsonian effects of amantadin

21:26:41 [hutals] also used for prevention of influenza A (amantadine)

21:27:48 [crusher] moa of acyclovir

21:27:57 [hutals] what is DOC for RSV?

21:28:04 [crusher] moa of acylovir

21:28:18 [Lorena] inhibits viral DNA polymerase

21:28:30 [Lorena] RSV gets Rivabirin

21:28:33 [hutals] inhibits viral DNA polymerase

21:29:21 [hutals] yep Ribavirin which inhibits RNA polymerase.....dont confuse with DNA polymerase of acyclovir

21:29:39 [crusher] very good all

21:30:04 [crusher] wht about moa of ziminavir/

21:30:29 [Lorena] R-ivabirin- R-sv - R-na polymerase

21:30:46 [hutals] good one lor

21:30:56 [jwls29] thanks lore

21:31:26 [Lorena] yw

21:32:01 [Lorena] inhib neuraminidase?

21:32:13 [hutals] i think all the "avir" drugs inhibit aspartate protease

21:32:55 [Lorena] oh ok

21:33:04 [crusher] yes lor..it inhibit neroamidases

21:33:46 [Lorena] oh good, i was guessing

21:33:50 [hutals] i thought it was a protease inhibitor like the other avirs

21:34:38 [crusher] chek out caplan 214 page very good summary of moa

21:35:50 [crusher] about the reverse transcriptase what is major s/e ofzalcitabine?

21:36:27 [kmonica26] pancreatitis,perphercal neuropathy

21:36:35 [hutals] neuropathy

21:37:20 [Lorena] i just know the s/e of RTI's in gral.: hematotoxic, neuropathy, lactic acidosis

21:37:38 [crusher] yes zalcitabine majoe s/e isperipheral neuropathy

21:38:09 [crusher] add onemore lor pancreatitis fpr diadinosine

21:38:18 [hutals] pancreatitis also, and neutorpenia, GI effects

21:38:33 [Lorena] ok, thanx

21:39:09 [crusher] zidovudinefamous one=====hematotoxic

21:39:49 [Lorena] side effects of PI's?

21:40:07 [hutals] lamivudine will not have peripheral neuropathy, so good alternative to avoid that particular SE

21:40:29 [crusher] indinavir .nephrolithoasis

21:40:54 [kmonica26] disordered lipid metabolism

21:40:54 [hutals] headache?

21:41:18 [crusher] alsoinhib of p450

21:41:54 [Lorena] very good

21:42:57 [Lorena] DOC for back packer's diarrhea?

21:43:16 [hutals] ritonavir acutally induces one p450 enz, but inhibits 2 other p450 enzymes....i have enuf trouble remembering which ones induce and inib...now they have combos?!?

21:43:34 [Lorena] lol

21:43:39 [crusher] metro

21:44:14 [Lorena] yes, the bug is giardia lamblia

21:44:20 [hutals] agree metro

21:45:01 [hutals] i was trying to figure out what bug causes back packers diarrhea....but metro covers many bugs

21:45:06 [hutals] so good choice

21:45:42 [Lorena] i didnt know the diarrhea by giardia lamblia was called like that before

21:45:59 [crusher] prophylaxix tx hiv of needle stick

21:46:15 [hutals] i didnt know until you just brought it up....thanks

21:47:05 [kmonica26] azt+3tc

21:47:13 [hutals] azt??

21:47:25 [Lorena] agree

21:47:41 [jwls29] agree with azt

21:48:21 [crusher] AZt +3Tc for i month n in high risk for 3 month

21:48:30 [hutals] good point to use in combo with 3tc, especially since it covers hep B

21:48:45 [hutals] they also work synergistically

21:49:38 [hutals] anything else to cover tonight?

21:49:50 [kmonica26] How about in Pregnancy? What dg used in HIV + mother?

21:49:57 [Lorena] i think we covered a lot

21:50:16 [crusher] azd in prgnant

21:50:24 [hutals] azt again would be my guess

21:50:47 [kmonica26] yes hutal and crusher

21:51:23 [crusher] but only in 2nd n 3rd trimester

21:51:25 [hutals] just for micro review....what percent of newborns of moms with HIV will have + HIV Abs at birth?

21:51:59 [crusher] n for neonat also ADv =6 week cos of verticle transmission

21:52:15 [kmonica26] 20% guessing

21:52:42 [crusher] i guess its high!

21:52:56 [Lorena] me too, very high

21:53:21 [hutals] this is a trick question. 100% of newborns will have HIV Abs at birth because the moms Ig pass to child.....but not all will become infected.

21:53:43 [kmonica26] interesting

21:54:01 [Lorena] thanx hutals

21:54:12 [hutals] after 6 months to a check you can recheck....without AZT i think it is 20% and with AZT i think goes down to 5 %

21:54:18 [hutals] or you can do PCR

21:54:21 [crusher] that support the ans of my q,s neonat azd for 6 week

21:54:23 [Lorena] ok, i have to go. See you guys tomorrow

21:54:32 [jwls29] i'm gonna go too

21:54:37 [jwls29] i'm sleepy

21:54:37 [hutals] but that was way back in micro, so dont quote me on that

21:54:41 [kmonica26] Me too

21:54:45 [kmonica26] Bye guys

21:54:51 [hutals] good nite all

21:54:55 [crusher] good night lorena and kmonica

21:54:55 [jwls29] bye

21:55:03 [Lorena] thanks for the great chat

21:55:04 [jwls29] i won't be here tomorrow

21:55:06 [crusher] good bbye all

21:55:14 [jwls29] we are still on for sat at 8?

21:55:41 [Lorena] yes, i will come on saturday

21:55:49 [hutals] me too

21:55:58 [jwls29] ok

21:56:06 [jwls29] c ya on saturday

21:56:10 [jwls29] bye

21:56:12 [hutals] lorena, are you posting chat?

21:56:36 [Lorena] yes, are you guys leaving too?

21:57:10 [hutals] i am, i was supposed to leave an hour ago....i'm late

21:57:41 [Lorena] i will post it ....oh yes, i forgot...thanks for staying hutals, we all apreciate it

21:58:10 [hutals] i learned alot in the last hour so it was worth it for me too......thanks and good nite

21:58:21 [Lorena] good night all

21:58:29 hutals exits from this room