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chat transcript: antimicrobials
20:07:11 [hutals] ok, ready to get started on antimicrobials?
20:07:12 [Lorena] do you want to start now? 20:07:18 [Lorena] yes 20:07:41 [kmonica26] yes 20:08:03 [jwls29] yes 20:08:55 [hutals] i'm trying to find a diagram on net, but cant. anyway, a previous question had pic with most common type pathway of transmission, which is transduction... 20:09:30 [hutals] they asked what was mech of action? 20:09:59 [Lorena] MOA of transduction? 20:10:50 [hutals] yes, sorry, that is what i meant.....the real question had a diagram of it rather than the word, but you had to know what it was and the mech of action of how its transferred 20:11:16 [Lorena] a donor bacteria or male gives ssome genetic material to a recipient -a female bacteria- by a F factor 20:12:12 [hutals] i think this is the one that is transferred from once cell to another via a phage 20:12:26 [Lorena] thats conjugation ...ops 20:12:51 [Lorena] yes, via a phage-the phage is the "transductor" 20:13:11 [hutals] and i remember something about transFormation being F-ree cells 20:14:00 [hutals] i guess that is more of a micro question, but i happen to have it written in this part of my notes 20:14:08 [Lorena] good one 20:14:51 [hutals] the part that got me was that they wanted you to recognize transduction from a pic?? so try to go over those at some point 20:15:07 [Lorena] ok 20:15:14 [jwls29] ty hutals 20:16:23 [Lorena] antibiotics that can cause crystalluria? 20:16:44 [jwls29] sulfonamides 20:17:05 [hutals] ethylene glycol 20:17:15 [Lorena] yes, very good jwls 20:18:20 [hutals] which drugs develop resistance by beta lactamase cleavage of beta lactam ring? 20:19:29 acestep1 enters this room 20:19:39 [hutals] hey ace 20:19:47 [Lorena] hi ace 20:20:03 [hutals] penicillincs and cephalosporins develop resistance in this manner....another previous real question 20:20:09 [jwls29] hi ace 20:20:14 [kmonica26] pencillin, caphalosporins 20:20:16 [Lorena] organisms have developed resistance to penicillins and cephalosporins 20:20:20 [acestep1] hi hutals n lor . how r u guys 20:20:34 [Lorena] hi ace, good and you? 20:20:35 [acestep1] hey jwls 20:20:41 [hutals] good, how bout u? 20:21:00 [acestep1] im good as well 20:21:06 [hutals] how does erythromycin develop resistance? (q bank question) 20:21:33 [kmonica26] methytranferase formation 20:22:06 [acestep1] agree 20:22:25 [hutals] yep, methylation of base in RNA 20:22:49 [Lorena] thanks 20:23:48 [Lorena] drugs that can cause disulfiram reactions? 20:24:10 [jwls29] metronidazole 20:24:32 [acestep1] metronida, chllorpropa, cefoteetan n pefperazone 20:24:33 [hutals] metro 20:24:41 [hutals] cefotetan 20:24:45 [hutals] cefamandole 20:24:48 [acestep1] oops sorry imean cefperazone 20:25:01 [hutals] cefoperazone 20:25:30 [acestep1] i think moxalactam as well 20:25:35 [hutals] chlorpropamide 20:25:38 [Lorena] metronidazole, cefotetan, cefoperazone, cefamandole, moxalactam, ketoconazole .....god job 20:25:59 [hutals] 65 yo female presents with prod cough, fever, lobar pneumonia seen on x-***. what is the drug of choice? (another q bank question) 20:26:36 [acestep1] pen /eph 20:26:55 [kmonica26] amoxicillin..strep pneumo 20:27:10 [Lorena] she has typical neumonia....penicillins or cephalosporins 20:27:10 [acestep1] imean penicillin s or cephlosporins ( 1st or 2nd gen 20:27:37 [Lorena] agree with ace, 1st or 2th generation 20:27:40 [hutals] this patient most likely has community aquired pneumonia, which is most commonly caused by strep pneumo. despite resistance, penicillin is still the drug of choice for the boards. in real life this is not the case 20:27:43 [jwls29] agree with pcn or cephalo 20:28:12 [acestep1] lol. agree 20:28:18 [hutals] ceph is 2nd choice for boards and #1 for real life 20:28:34 [hutals] 20:28:46 [Lorena] patient with gonorrhea , allergic to penicillins...tx? 20:28:48 [acestep1] . k 20:29:19 [hutals] aztreonam 20:29:36 [acestep1] ideally its ceftriazone but since hes allergic i think erythro? 20:30:05 [jwls29] erythro? 20:30:25 [kmonica26] I think erythro or azithro 20:30:29 [acestep1] erythormycin 20:31:02 [Lorena] yes, erythro, azythro or fluoroquinolones 20:31:30 [acestep1] k 20:31:39 [Lorena] aztreonam probably too but it is only IV 20:31:52 [hutals] this was also a real question given as a young girl who developed UTI and allergic to penicillin. the common factor is that they are both gram neg (gonorrhea and e.coli for UTI). according to kap, a pt with gram neg who is allergic to pens should be given aztreonam to specifically cover gr neg 20:32:45 [Lorena] very good everybody 20:33:23 [acestep1] ic . ididnt know tht hutals 20:33:33 [hutals] azithromycin will cover gr -, but clarith will not cover gonorrhea 20:33:33 [Lorena] what if the patient is pregnant, gonorrhea+ allergy to penicillin? 20:34:18 [kmonica26] azithro is safe 20:34:26 [kmonica26] in preganancy 20:34:48 [hutals] i'm not sure if can give with pregnancy? i know you can give azith with pregnancy, so probably best choice 20:34:56 [acestep1] i still go for erythro 20:35:08 [Lorena] excellent monica 20:35:11 [acestep1] k 20:35:31 [Lorena] and hutals 20:35:31 [kmonica26] thanks 20:36:00 [Lorena] erythromycin too but not in the estolate form because it can cause cholestasis specially dangerous in pregnancy 20:36:28 [acestep1] yes . i forgot abt tht 20:36:31 [Lorena] only erythromycin base or ethylsuccinate 20:36:55 [acestep1] yes. agree 20:37:22 [hutals] what drug most commonly causes C. diff? what treatment? 20:37:51 [kmonica26] clindamycin...treat with vanco or metronidazole oral 20:38:05 [Lorena] clindamycion, lyncomycin, ampicillin but [practically all broad spectrum antibiotics. Tx is metronidazole and vanncomycin is back up 20:38:06 [acestep1] amphicllin 20:38:19 [jwls29] agree 20:38:22 [acestep1] agree with lor 20:38:50 [hutals] C diff caused MC by clindamycin and ampicillin, treat with metro first....vanco if drug resistance 20:39:19 [Lorena] what drug has the infamous side effect of interstitial nephritis? 20:39:37 [jwls29] methicillin 20:39:40 [kmonica26] methicillin 20:39:42 [acestep1] methicillin 20:39:51 [hutals] agree 20:39:58 [acestep1] i think even nsaids n sulfonamides 20:40:00 [Lorena] good! 20:40:37 [kmonica26] which drugs cause phototoxicity? 20:40:40 [hutals] what drug gives "red man syndrome"? what other side effects for this drug? 20:40:41 [Lorena] yes, very probably 20:40:48 [acestep1] sorry sorry we r discussing antibiotics only 20:40:52 [jwls29] tetracycline 20:41:02 [jwls29] vancomycin 20:41:04 [hutals] fluoroquins 20:41:08 [hutals] tetracycline 20:41:15 [kmonica26] vanco for hutals 20:41:15 [jwls29] for red man sdme 20:41:30 [acestep1] i think sulfonamides n tetra n quinolones 20:41:44 [acestep1] tht was for monica 20:41:46 [kmonica26] and yes answer is sulphonaamides, tetracyclies and fluoroq 20:41:55 [Lorena] red man sx is for vanco 20:42:03 [acestep1] for read man - vanco 20:42:35 [Lorena] release of histamine so flushing and hypotension 20:42:48 [hutals] yes, red man is vanco. also ototox, nephrotox, hypersensitivity 20:42:52 [acestep1] agree 20:43:14 [hutals] very good all 20:44:17 [Lorena] tx for syphilis in penicillin allergy? 20:44:23 [hutals] real question had MOA of antifungals (amphotericin or nystatin)? 20:44:57 [acestep1] tetracyclines 20:45:07 [kmonica26] ergosterol interction and makes pores there 20:45:16 [acestep1] oops sorry imean erythro 20:45:25 [jwls29] amphotericin 20:45:27 [Lorena] agree with monica 20:45:30 [acestep1] agree with monica 20:45:50 [hutals] Patients with penicillin allergy can be treated with alternative regimens if they have primary or secondary syphilis. Penicillin is the only effective drug for neurosyphilis; oral desensitization should be accomplished before treatment of penicillin-allergic patients. 20:46:22 [acestep1] ic 20:46:40 [acestep1] from where did u get this 20:46:50 [Lorena] ver good hutals , tetracyclines is also a choice 20:47:10 [hutals] http://www.aafp.org/afp/990415ap/2233.html 20:47:16 [Lorena] it is in k a pl an , at the end of the chapter in q's and asnwers too 20:47:47 [acestep1] k . thnx both of u 20:47:54 [kmonica26] 16-year-old female patient presents with complaints of a 20:48:13 [kmonica26] non-productive cough, low-grade fever, and a headache. The 20:48:23 [Lorena] yw ace 20:48:26 [kmonica26] physician also notes a non-purulent otitis media. She is 20:48:36 [kmonica26] treated with an antibiotic that inhibits the translocation 20:48:49 [kmonica26] of the growing peptide chain along the mRNA. The antibioti 20:49:01 [kmonica26] c the patient was given was 20:49:23 [hutals] erythromycin?? 20:49:42 [kmonica26] yep correct 20:49:45 [jwls29] azithromycin? 20:49:48 [acestep1] tetracyclines? 20:49:49 [kmonica26] 20:50:25 [hutals] sounds like atypical pnemonia where the macrolides are the drug of choice 20:50:34 [kmonica26] MOA of Macrolides...basically another way of asking 20:50:46 [acestep1] k 20:50:50 [kmonica26] yes U r absolutely right 20:50:56 [kmonica26] hutals 20:51:15 [hutals] good one because the boards can never seem to ask a straight forward question anymore 20:51:43 [kmonica26] tru 20:51:51 [kmonica26] true 20:51:58 [hutals] what is the DOC for anaerobes? 20:52:17 [jwls29] clindamycin? 20:52:30 [kmonica26] clinda? 20:52:37 [acestep1] metronida? 20:53:12 [Lorena] i would go for metro 20:53:23 [hutals] DOC for anaerobes is Metronidazole....at least according to q bank. clinda i think is #2 (like in alcoholic because of disulfuram reaction ) 20:53:59 [acestep1] k . thnx 20:54:13 [Lorena] DOC for ulcerative colitis? 20:54:23 crusher enters this room 20:54:30 [acestep1] i think even k aplan mentions it as doc in metro 20:54:47 [acestep1] sulfasalazine 20:54:54 [Lorena] hi crush 20:54:57 [acestep1] hi crush 20:55:09 [jwls29] sulfasalazine 20:55:15 [jwls29] hi crusher 20:55:18 [kmonica26] agree with jwls 20:55:20 [hutals] Corticosteroids 20:55:37 [acestep1] ic 20:55:49 [crusher] hello all 20:55:53 [acestep1] yes could b 20:56:03 [hutals] hey crush 20:56:17 [Lorena] yes, very good, sulfasalazine when cleaved in the intestin by bacteria , it forms a compound that has local antiinflamatory properties ...also steroids ...very good! 20:56:35 [acestep1] k 20:57:12 [hutals] so sulfasalazine is first choice for UC? thanks 20:57:19 [hutals] didnt know that one 20:58:10 [Lorena] yes, the compound is 5-aminosalicylic acid...sounds antiinflamatory 20:58:29 [hutals] ah yes, that one sounds familiar 20:58:39 [acestep1] yup plus sulfadiazine 20:59:28 [hutals] why can't they just call it ulcerative colitis....azine, or ol, or something easier to remember 20:59:50 [acestep1] lol 21:00:05 [acestep1] ok s/e of aminoglycosides 21:00:07 [Lorena] sulfadiazine+pyrimethamine , what is this combo used for? 21:00:38 [acestep1] toxoplasmosis? 21:00:43 [Lorena] aminoglycosides are nephrotoxic specially if combined with loops, also ototoxic 21:01:08 [acestep1] v gd 21:01:12 [hutals] PCP, salmonella 21:02:00 [acestep1] aslo they r neuromuscular blker so when given with anesthetics they act synergistically 21:02:16 [hutals] what drug can cause hemolysis in G6PD def pts and is also is contraindicated in pregnancy because causes kernicterus from inc unconjugated bilirubin? 21:02:18 [Lorena] yes toxo...good 21:02:28 [acestep1] i thought pcp- cotrimoxazole 21:02:48 [crusher] sulfa drugs .? 21:02:53 [Lorena] sulfadiazines, SMX/TMP 21:03:05 [jwls29] sulfa 21:03:21 [acestep1] agree 21:03:55 [hutals] oops, i got mixed up on lor's question, i thought it said cotrimoxazole which is trimethoprim and sulfamethoxazole 21:04:27 [hutals] anyway, thats the answer to my question, and also happens to be used for PCP and salmonella 21:04:48 [hutals] aka TMP SMX 21:04:53 [hutals] or bactrim 21:05:20 [Lorena] ok, thanks 21:05:27 [acestep1] k. np 21:05:35 [hutals] you all got it right....very good 21:06:04 [Lorena] gray baby syndrome? signs and symptoms , drug that caused? 21:06:06 [hutals] and its a sulfa drug, so thats correct as well 21:06:19 [jwls29] chloramphenicol 21:06:25 [acestep1] chroampheicol 21:06:30 [hutals] is it choramphenicol?? 21:06:44 [Lorena] yes 21:06:45 [crusher] cholampenicol 21:06:48 [acestep1] i think it interferes with mitochondria 21:07:37 [Lorena] i just ask for signs and symptoms becausethey will probably just decribe the baby ...and ask what drug caused it 21:07:50 [hutals] i dont remember exact signs, but baby looks a bit gray 21:07:56 [acestep1] agree 21:08:15 [acestep1] i think diff in breathing n cynosis 21:08:16 [Lorena] abdominal distention, vomiting, cyanosis, irregular respiration, hypothermia, CV colapse 21:08:46 [acestep1] so basically all s/s of ischemia 21:09:14 [Lorena] yes, so i think you are right and it interferes with mitochondria- 21:09:33 [acestep1] k 21:09:33 [hutals] i think the cyanosis is the part that produces the "gray" appearance....right? 21:09:58 [Lorena] yes 21:10:20 [acestep1] ya n then in teh end cuz of damage 2 brain n dec atp u have cvs collpase n dec temp 21:10:49 [hutals] ""Gray syndrome" occurs if newborns (especially premature babies) are given chloramphenicol for a bacterial infection. Babies this young do not have the necessary enzymes that allow the liver to metabolize this drug appropriately. The chloramphenicol accumulates in the baby's blood stream, causing 21:10:53 [hutals] hypotension (low blood pressure), cyanosis (blue coloring of lips, nail beds, and skin from lack of oxygen in the blood), and often death." 21:10:54 [acestep1] i think cvs collpase with all od n also resap diff 21:11:35 [acestep1] ok . i thing is it exc by glucoronidation? 21:12:00 [acestep1] n i think mostly was given for h.influenza infections 21:12:13 [crusher] if someone is allergic topenecillin can take cephalosporin?if yes why if not why? 21:12:31 [hutals] good point lorena because they wont be nice enough to say "gray baby" in the question 21:12:31 [kmonica26] But the commonest side effevt of chloramphenicol is dose dependent BOne marrow suppression..I remmeber seeing a question where it was asked 21:12:38 [acestep1] no - cuz bothr b lactams 21:12:56 [Lorena] no, because cross allergy 21:13:21 [jwls29] agree 21:13:27 [crusher] good.no cos both pen n cepholo has samw moa 21:13:29 [Lorena] thanks hutals 21:13:39 [acestep1] yes monica but this bms is much less than bms with other drugs eg czrbemezapine 21:13:45 [hutals] choramphenicol is also cause of aplastic anemia (parvo is other cause of this) 21:14:05 [kmonica26] agree ace 21:14:08 [acestep1] agree 21:14:28 [Lorena] ok 21:15:15 [acestep1] guys im really sleepy 21:16:00 [acestep1] i guess ill read the transcript 21:16:13 [acestep1] 21:16:20 [hutals] ok, good nite ace 21:16:23 [crusher] whts the mechanismof resistance of penicillin 21:16:34 [acestep1] ill see u guys tom . tc 21:16:40 [Lorena] see you tomorrow ace 21:16:46 [kmonica26] beta lactum production 21:16:48 [acestep1] gn all of u 21:16:56 [kmonica26] sory lactamase 21:17:00 [hutals] beta lactamase 21:17:01 [Lorena] good morning to you 21:17:06 [kmonica26] good note ace 21:17:25 [acestep1] i think 3 - b lactamase, dec permeability 21:17:29 [crusher] good nite ace 21:17:39 [acestep1] ya . lol . its morning 21:17:58 [acestep1] gn all of u. 21:18:19 [crusher] b ,lactamase (penicillinase) break lactam ring 21:18:23 [Lorena] agree beta lactamase 21:18:42 [hutals] what is DOC for CMV? 21:19:01 [Lorena] ganciclovyr 21:19:06 [kmonica26] ganciclovir 21:19:10 [crusher] acylovir.. 21:19:10 [jwls29] ganciclovir 21:19:24 [crusher] oops yes gan 21:19:52 [hutals] gancyclovir is DOC. acyclovir is the distractor 21:20:23 [Lorena] tx of CMV resistant to ganciclovir? 21:20:44 [crusher] foscarnet 21:20:46 [hutals] foscarnet 21:20:56 [kmonica26] foscaret? 21:21:04 [Lorena] yes 21:21:14 [jwls29] agree 21:21:22 [Lorena] good everybody 21:21:50 [hutals] forcarnet is given to AIDS pts who often get CMV retinitis. what AIDS drug is contraindicated with foscarnet? 21:22:12 [crusher] moa of amantadine 21:22:13 [Lorena] pentamidine 21:22:19 [hutals] and why is it contraindicated? 21:23:02 [hutals] amantadine interferes with attachment, penetration and uncoating of virus 21:23:05 [Lorena] because increases renal toxicity 21:23:37 [kmonica26] and hypocalceamia 21:23:49 [Lorena] agree with hutals , thats why it is only for prophylaxis 21:23:53 [crusher] or uncoating 21:24:22 [crusher] yes good it prevent viral pentration n uncoating 21:24:33 [hutals] yes dont give with pentamidine because renal tox and hypocalcemia 21:25:06 [hutals] AZT should not be given with ganglyclovir because both are neutropenic 21:25:13 [Lorena] jus to remember , mention the anti parkinsonian effects of amantadin 21:26:41 [hutals] also used for prevention of influenza A (amantadine) 21:27:48 [crusher] moa of acyclovir 21:27:57 [hutals] what is DOC for RSV? 21:28:04 [crusher] moa of acylovir 21:28:18 [Lorena] inhibits viral DNA polymerase 21:28:30 [Lorena] RSV gets Rivabirin 21:28:33 [hutals] inhibits viral DNA polymerase 21:29:21 [hutals] yep Ribavirin which inhibits RNA polymerase.....dont confuse with DNA polymerase of acyclovir 21:29:39 [crusher] very good all 21:30:04 [crusher] wht about moa of ziminavir/ 21:30:29 [Lorena] R-ivabirin- R-sv - R-na polymerase 21:30:46 [hutals] good one lor 21:30:56 [jwls29] thanks lore 21:31:26 [Lorena] yw 21:32:01 [Lorena] inhib neuraminidase? 21:32:13 [hutals] i think all the "avir" drugs inhibit aspartate protease 21:32:55 [Lorena] oh ok 21:33:04 [crusher] yes lor..it inhibit neroamidases 21:33:46 [Lorena] oh good, i was guessing 21:33:50 [hutals] i thought it was a protease inhibitor like the other avirs 21:34:38 [crusher] chek out caplan 214 page very good summary of moa 21:35:50 [crusher] about the reverse transcriptase what is major s/e ofzalcitabine? 21:36:27 [kmonica26] pancreatitis,perphercal neuropathy 21:36:35 [hutals] neuropathy 21:37:20 [Lorena] i just know the s/e of RTI's in gral.: hematotoxic, neuropathy, lactic acidosis 21:37:38 [crusher] yes zalcitabine majoe s/e isperipheral neuropathy 21:38:09 [crusher] add onemore lor pancreatitis fpr diadinosine 21:38:18 [hutals] pancreatitis also, and neutorpenia, GI effects 21:38:33 [Lorena] ok, thanx 21:39:09 [crusher] zidovudinefamous one=====hematotoxic 21:39:49 [Lorena] side effects of PI's? 21:40:07 [hutals] lamivudine will not have peripheral neuropathy, so good alternative to avoid that particular SE 21:40:29 [crusher] indinavir .nephrolithoasis 21:40:54 [kmonica26] disordered lipid metabolism 21:40:54 [hutals] headache? 21:41:18 [crusher] alsoinhib of p450 21:41:54 [Lorena] very good 21:42:57 [Lorena] DOC for back packer's diarrhea? 21:43:16 [hutals] ritonavir acutally induces one p450 enz, but inhibits 2 other p450 enzymes....i have enuf trouble remembering which ones induce and inib...now they have combos?!? 21:43:34 [Lorena] lol 21:43:39 [crusher] metro 21:44:14 [Lorena] yes, the bug is giardia lamblia 21:44:20 [hutals] agree metro 21:45:01 [hutals] i was trying to figure out what bug causes back packers diarrhea....but metro covers many bugs 21:45:06 [hutals] so good choice 21:45:42 [Lorena] i didnt know the diarrhea by giardia lamblia was called like that before 21:45:59 [crusher] prophylaxix tx hiv of needle stick 21:46:15 [hutals] i didnt know until you just brought it up....thanks 21:47:05 [kmonica26] azt+3tc 21:47:13 [hutals] azt?? 21:47:25 [Lorena] agree 21:47:41 [jwls29] agree with azt 21:48:21 [crusher] AZt +3Tc for i month n in high risk for 3 month 21:48:30 [hutals] good point to use in combo with 3tc, especially since it covers hep B 21:48:45 [hutals] they also work synergistically 21:49:38 [hutals] anything else to cover tonight? 21:49:50 [kmonica26] How about in Pregnancy? What dg used in HIV + mother? 21:49:57 [Lorena] i think we covered a lot 21:50:16 [crusher] azd in prgnant 21:50:24 [hutals] azt again would be my guess 21:50:47 [kmonica26] yes hutal and crusher 21:51:23 [crusher] but only in 2nd n 3rd trimester 21:51:25 [hutals] just for micro review....what percent of newborns of moms with HIV will have + HIV Abs at birth? 21:51:59 [crusher] n for neonat also ADv =6 week cos of verticle transmission 21:52:15 [kmonica26] 20% guessing 21:52:42 [crusher] i guess its high! 21:52:56 [Lorena] me too, very high 21:53:21 [hutals] this is a trick question. 100% of newborns will have HIV Abs at birth because the moms Ig pass to child.....but not all will become infected. 21:53:43 [kmonica26] interesting 21:54:01 [Lorena] thanx hutals 21:54:12 [hutals] after 6 months to a check you can recheck....without AZT i think it is 20% and with AZT i think goes down to 5 % 21:54:18 [hutals] or you can do PCR 21:54:21 [crusher] that support the ans of my q,s neonat azd for 6 week 21:54:23 [Lorena] ok, i have to go. See you guys tomorrow 21:54:32 [jwls29] i'm gonna go too 21:54:37 [jwls29] i'm sleepy 21:54:37 [hutals] but that was way back in micro, so dont quote me on that 21:54:41 [kmonica26] Me too 21:54:45 [kmonica26] Bye guys 21:54:51 [hutals] good nite all 21:54:55 [crusher] good night lorena and kmonica 21:54:55 [jwls29] bye 21:55:03 [Lorena] thanks for the great chat 21:55:04 [jwls29] i won't be here tomorrow 21:55:06 [crusher] good bbye all 21:55:14 [jwls29] we are still on for sat at 8? 21:55:41 [Lorena] yes, i will come on saturday 21:55:49 [hutals] me too 21:55:58 [jwls29] ok 21:56:06 [jwls29] c ya on saturday 21:56:10 [jwls29] bye 21:56:12 [hutals] lorena, are you posting chat? 21:56:36 [Lorena] yes, are you guys leaving too? 21:57:10 [hutals] i am, i was supposed to leave an hour ago....i'm late 21:57:41 [Lorena] i will post it ....oh yes, i forgot...thanks for staying hutals, we all apreciate it 21:58:10 [hutals] i learned alot in the last hour so it was worth it for me too......thanks and good nite 21:58:21 [Lorena] good night all 21:58:29 hutals exits from this room |
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