Why hypercalcemia in sarcoidosis?

[Caboose]

Dang it. I forgot this and searching the internet is becoming frustrating. I think I'm losing my Google touch.

Does anyone know off the top of your head why Sarcoidosis results in calcium chaos?

Thanks!

Caboose.

[rahulb]

epitheloid cells activate vitamin D and increase Ca2+ absorption

[Can2carib]

Epitheliod cells in Sarcoidosis contain 1 alpha hydroxylase which completes the second hydroxylation to form the active form of vitamin D. This leads to hypervitaminosis D. Vit D then leads to increased intestinal absorption of Ca2+ leading to hypercalcemia. Hope that helps...