A 52-year-old male with chronic respiratory difficulty dies from bronchopneumonia. At autopsy, the anterior spinal nerve roots are atrophic, and spinal cord anterior horns show neuronal loss with gliosis. These findings are most consistent with:
A Gullain-Barre syndrome
C Rabies infection
E Amyotrophic lateral sclerosis
(B) CORRECT. Poliovirus infection leads to destruction of anterior horn cells. The anterior (motor) spinal nerve roots then atrophy.
-I thought this was a cheesy question... it didn't mention corticalspinal tract, so i guess if it's just anterior horns, polio would be the best choice.
M.D., PGY-3 Internal Medicine