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  1. #1
    md90's Avatar
    md90 is offline Senior Member
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    Arrow "monday disease"

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    was reviewing CV drugs in FA, and under toxicities of nitroglycerin and isosorbide dinitrates, it had "monday disease"... this is related to muscle pain in horses so what does it have to do with humans? Can someone please explain to me. Thank you..
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
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    md90's Avatar
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    wcb22, tommyk, IMGSurvivor, Demarco, student-2, rrod, electra,...... anyone??? does anyone know what "Monday's Disease" has to do with humans?

    for horses.. they get the disease b/c of overfeeding of carbohydrates;

    the connection that I can make for humans.. is the nitrates (isosorbide dinitrates) which produce metHb and cause hemolytic anemia because the person may have a gluc-6P-Dehydrogenase deficiency... this causes low oxygen saturation and destruction of RBCs prematurely respectively...

    Am I on the right track? or is there something else that I'm missing????
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  3. #3
    BiscayneBlvd is offline Junior Member 510 points
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    hey

    i don't exactly know if this is right...but i think this is what i remember

    monday blues.....

    a person is around the substances during the week (aka like a factory) and so are used to the substances..when they go home on friday they dont deal with it for 2 days so they come off of it....but when they go back on monday they are reexposed to the substances...as a result they have the blues on monday b/c they know whats going to happen

    i hope that helps
    i think thats right

    bb

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    md90's Avatar
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    Lightbulb went off in my head

    ohhhh... I'm so stupid!!! lol!!! the "light bulb" went off... thank you I just realized with these drugs, there needs to be a resting period... duh!!! It's time to rest the mind... good night!!!
    Last edited by md90; 06-01-2006 at 10:54 PM.
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”

  5. #5
    twatson is offline Newbie
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    Monday disease is a toxicity that happens to those who are exposed to Nitroglycerin or isosorbide dinitrate industrially, like who work in construction or demolition industries, mix concrete, do plaster, ect.
    During the week, Monday to Friday, they are exposed to the vasodilating action, so they build up a tolerance. If they are off on Saturday and Sunday the tolerance is lost. So when they go back to work on Monday the tachycardia, hypotension, flusing and headache return, but a tolerance is built up again by the next day.

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