well it was just the two of us, but we got quite a bit done.. the topic was immunopathology, and we also did some genetics... here's a copy...

[md90] rainz.. here for the goljan chat?
[rainz] yup
[rainz] jus wanna see wats goin on
[rainz] i was kinda in the middle of qbank tho
[md90] ok.. am going to wait to see anyone else shows up,..
[rainz] ok
[rainz] i'll be doing q-bank
[rainz] i'll doing in later.
[md90] we usually just ask questions, and have discussions;
[rainz] yea i read
[rainz] yur previous
[rainz] post
[md90] ok... that sounds good; today's topic is immunopathology
[rainz] ok
[rainz] i was here at 8pm
[rainz] but nobody was around
[md90] sorry... lost track of the time; am trying to get ready for clinical rotations next month plus do quick reviews for the exam...
[rainz] oh.. when are you taking it?
[md90] can't believe how fast time goes by...
[rainz] i know...june is almost over!
[md90] I want to take it in two weeks, but it really depends on ECFMG.. I have not rec'd my ticket as of yet; but have been approved..
[rainz] oh
[rainz] yea im taking mine in 2 weeks as well
[md90] I don't know if i'm ready.. but am anxious ("antsy") to take the exam.. does that make sense?
[rainz] immunopatho? so hypersensitivies?
[md90] yep..
[rainz] yea i get wat you mean
[rainz] i think you are ready- you have been following tommy ks posts
[rainz] physio is a struggle for me
[md90] I do good on his posts, so I hope that is a good sign...
[rainz] im sure it is.
[rainz] have confidence in yourself
[rainz] you will do fine.
[md90] y'know.. i like step up; been reviewing that these past few weeks, and writing.. reading and writing.. they have a systematic approach which I like..
[md90] it's making me understand the physio + path much better...
[rainz] yea i have that book too, i havent paid much attention to it
[rainz] i went through it once a couple months back
[md90] have you tried that? maybe connecting the physio and path.. maybe that will help to "connect"
[rainz] i'll go through the CNS there
[rainz] step up?
[md90] yeah..
[rainz] yea
[rainz] yea i will try that
[rainz] i need to do a HY review of biochem, anatomy and behav tomorrow
[rainz] then HY review of patho/physio the next day
[rainz] it doesnt look like anyone else is coming
[md90] I like what they did with CNS and behavior.. they put it together as one system.. and the basics of medicines..
[md90] let's get started..
[md90] this will be a short topic... but it's good..
[rainz] ok
[rainz] lets see
[md90] and i'm going to try something tonight.. double jump or/and triple jump questions..
[md90] like the USMLE style questions..
[rainz] ok
[md90] let's start easy...
[rainz] 1min
[rainz] do u have
[rainz] notes
[rainz] infront of u?
[md90] I don't have notes.. but have questions that I made up.. or that goljan says in his audio..
[rainz] ok
[md90] i try to go on my "memory".. )
[rainz] ok
[rainz] lets do this
[md90]
[rainz] what hypersensitivity is for uticaria?
[rainz] lol
[rainz] ??
[md90] type III??
[rainz] no
[rainz] type 1
[rainz] i think
[rainz] let me look at my notes
[md90] uticaria is the reaction of the skin..
[md90] is it activated by the mast cells?
[md90] if so.. type I is right
[rainz] right and type 1 hypersensitivies are asthma, allergy and anaphylatoxin
[rainz] yes it is
[md90] male, 5yrs, comes to the ER; can hear audible wheezing, and gasping.. mom states that he just ate one peanut? what is the mechanism of this reaction?
[rainz] umm he has an allergic reaction rite?
[rainz] the mast cells release histamine
[md90] right..
[rainz] mast and basophil
[md90] would be considered anaphylactic.. being immediate..
[md90] mast cells are right, but not basophils
[rainz] ok
[rainz] umm
[rainz] i dunno.
[md90] would eosinophils.. , why? they are invited to the area by the mast cells
[rainz] rite
[rainz] yur anaphylactic are yur bee stings
[md90] not really, rainz.. anaphylactic can be more than bee stings...
[rainz] ok... wat hypersensitivity is autoimmunie hemolytic anemia?
[rainz] ok.. give me an example
[md90] type II
[rainz] right
[md90] antibody-dependent reaction.. the best example would be the mother-fetus
[rainz] rite
[rainz] rheumatoid arthritis?
[rainz] what does that categorize under?
[md90] can't remember..
[rainz] its type 3
[rainz] remember that
[md90] ok.. thanks..
[rainz] type 2 hypersensitivites have specific targets... like myasthenia gravis
[md90] and grave's disease..
[rainz] what is the receptor for Myasthenia?
[rainz] rite
[md90] acetylcholine
[rainz] good, what bout a patient coming in with hemoptysis..
[rainz] what is the dz? and what is the hypersensitivity type?
[md90] would that be type IV.. and possible dz is TB
[rainz] hemoptysis and basement membrane antibodies...
[rainz] thats not what i was thinking of.
[md90] type IV has to do with delayed reactions, granulomas, virus-infected cells..
[rainz] patient with hemoptysis, and basement membrane antibodies...what is the dz? and hypersensitivity?
[md90] basement membrane.. am thinking type III
[rainz] right.. type 4 can also be contact dermatitis, poiseon ivy
[md90] lupus?
[rainz] no its type 2- remember... type 2 is with yur specific target - the dz was Good Pasture with the basement memb
[rainz] antibody
[rainz] lupus is type 3
[md90] argggghhhh.. mind was focusing type 3.. hard to change the mind once set
[rainz] i have a stupid way of remembering this stuff.. i dunno if it'll work for you
[md90] give it to me.. and i'll try...
[rainz] ok
[rainz] well type 2 are myasthenia, graves, autoimmune, good pasture, pernicious anemia ... all these focus on one part of the body
[rainz] like the eyes, kidney, ileum
[rainz] but the type 3 - focus on everything... like yur rheumatoid arthritis- u got bones all over.
[rainz] pans/wegners- vasculities -- all over - its tyep 3 as well
[rainz] same for LUPUS... you got a rash first on yur face then all over.. type 3 as well
[rainz] only exception in glomerulonephritis in tiype 3
[rainz] its really stupid way of thinkin bout it.. but it works
[rainz] also, the type 2 as a specific target(ACH receptors, TSH recep, Rh of rbs, basement mem, parietal cell)...and type 3 is a antibody antigen complez
[rainz] you there?
[md90] i'm writing.. it down..
[md90] I have to write it down.. it sticks better... then repeat and repeat.................
[rainz] oh ok
[rainz] i hope that helps
[md90] it actually makes sense... once you start thinking about the diseases and symptoms...
[md90] thanks..
[rainz] good so its not THAT stupid of a way ...lol
[rainz] ok lets go onto Autoimmune diseases??
[rainz] what are the autoantibodies for SLE?
[md90] no it's not stupid... another view..
[rainz] ok lets go thru Autoimmune dzs
[rainz] what are the signs/symptoms a patient would present with SLE?
[md90] SLE-- ANA and anti-phospholipid antibodies
[rainz] ok.. there is also anti-ds DNA
[rainz] and Anti-Smith for SLE
[md90] main one.. (USMLE knows that we know this)... butterfly rash on the face..
[rainz] what bout drug induced SLE? what antibody will be present?
[rainz] another symptom for SLE is.... PAIN
[md90] antihistone ABs for drug induced
[rainz] good
[rainz] have you heard of Libmans endocarditis?? or sumthing?
[md90] that was a good question.. b/c I forgot about drug induced
[md90] yes..
[rainz] i know it relates to SLE... but in what way?
[md90] remember goljan talking about it..
[rainz] yea
[rainz] i looked it up
[md90] libman-sacks.. are vegetations on the mitral valve..
[rainz] all it says is libman sack endocardities- associated with sle involves mitral valve
[rainz] yea... vegetations
[rainz] libman sacks is a nonbacterial verrucous endocarditis
[md90] remember that SLE affects all body systems.. but believe that this is a late sign.. as the disease progresses
[rainz] k
[md90] hold on..
[rainz] k
[rainz] what drugs induce SLE?
[md90] i looked it up.. and we know that it's type III.. antigen-antibody complex.. the body acting against self..form of endocarditis
[md90] most common drug is procainamide..
[md90] also hydralazine..
[rainz] isonizid
[rainz] and phenytoin as well
[md90] what is requirement for successful transplantation?
[rainz] patient comes in with morning stiffness, dry mouth and dry eyes. What is the diagnosis and what is the autoantibody?
[rainz] ummmm
[md90] Sjorgen's syndrome..
[rainz] what do youmean?
[rainz] type 4?
[rainz] is graft- host
[md90] for a transplantation to be successful, what is the important factor?
[rainz] the bloods have to match?
[rainz] lol
[rainz]
[md90] besides just the blood being matched.. you need to make sure that HLA's match..
[rainz] CD8
[rainz] oh yea yea
[rainz] HLA D2 AND D3
[rainz] omg... i didnt know HLA was for transplantation!
[md90] the answer to your question.. was it Sjogen syndrome? but can't remember the autoantibodies
[rainz] D3/D4 are for diabetes ritte?
[md90] HLA is important.. -A, -D, -B..
[rainz] yes it was Sjogren
[rainz] autoantibodies for Sjogren
[rainz] are
[rainz] La and Ro
[rainz] remember!
[md90] that's right for diabetes..
[md90] remember the Ro now.. totally forgot the La..
[rainz] Goljan was like "they came up with that back when they had that song - DO RAY ME"
[rainz] THAS HOW I REMEMber it
[md90] that's like that song.. "my favorite things" by the sound of music.. La, Ro..... Ro, La... sjogen's syndrome...
[md90] great brains think alike..
[rainz] lol
[md90]
[rainz] ok so a pateind comes in with dystrohic calcification, cyanosis of his digits in the cold, and telangiectasias, what ist he dz?
[md90] that's not CREST..???
[rainz] yes it is Crest Syndrome.
[md90] OMG!!!
[rainz] I only gave you a couple of the CREST pneumonics
[rainz] lol
[rainz] jus to make it hard...haha im evil
[md90] always get that wrong on every test that I take.. and to get it right.. i'm happy!!!
[md90]
[rainz] Calcinosis, raynaud, esophageal dysmotility, sclerodactyly, Telangiectasia
[rainz] lol
[rainz] Good
[rainz] wat is tha autoantibody?
[md90] serum ANA
[rainz] you still celebrating?
[rainz] lol
[rainz] no.. its anticentromere
[md90] serum anti-toperisomerase antibody..
[rainz] anti topoisomerase is for diffuse scleroderma whitch is autoantibody Scl70
[rainz] Crest is LOCALIZED
[md90] yep... i looked it up..
[rainz] Crest is anticentromere
[md90] ok.. have a question..
[rainz] antimitochondrial is....primary biliary cirrhosis?
[rainz] i always get those mixed up
[md90] male, 4yrs, comes into the clinic... has been having sinus-cold the past few weeks, take his blood for analysis,and it shows: decreased IgM, normal IgG, increased IgA and IgE. what is the dz?
[rainz] wiscott
[md90] yep..
[rainz] phew
[md90] right..
[rainz] thanks!
[md90] most common immunodef disease worldwide? (easy one)
[md90] most common fungal infection associated with it?
[rainz] HIv?
[md90] right..
[rainz] fungal-- ummm cryptococcus , or pneuocystis carnii
[md90] cryptococcus
[rainz] ok
[md90] good..
[rainz] an infant comes in with tetany, t cell deficiency and hypocalcemia
[md90] another question..
[rainz] this is easy
[md90] digeorge
[rainz] what arches?
[md90] 3
[rainz] and
[md90] and 4
[rainz] good
[rainz] also, remember they have recurrent viral and fungal infxns
[rainz] i hate common variable
[rainz] dz
[rainz] i hate IMMUNOLOGY
[rainz] :an
[md90] female comes in complaining of wrist complaint that you find that she has carpal tunnel syndrome; through further investigation, notice that she sometimes has arrhythmias of the heart, and her liver and spleen are somewhat enlarged... what is the possible dz?
[md90] understand that immuno is becoming a hot topic for USMLE...
[rainz] HMMMM
[md90] what are techniques to diagnose this?
[rainz] ok, well she has carpel tunnel... median nerve.. but that isnt getting me anywhere...
[rainz] arrithmia... liver and sleep enlarged....hmmm
[rainz] sickle?
[rainz] lol
[rainz] im not sure. can you give me multiple choice?
[md90] she states that her mother had dementia due to alzeimer's; the protein is coded by chromosome 21
[rainz] downs
[md90] A. scleroderma
[md90] B. hereditary angioderma
[md90] C. Raynaud's phenomenon
[md90] D. Primary Amyloidosis
[md90] E. Down's Syndrome
[rainz] downs
[md90] that was supposed to be the detractor..
[rainz] ohhhhhhhhhh
[rainz] is it primary amyloidosis?
[md90]
[md90] yeah..
[md90] right..
[rainz] oh
[rainz] how wod i have known that?
[rainz] well primary amyloidosis ....is in alzhiemers
[md90] amyloidosis.. there are three types.. primary and secondary then senile cerebral...
[rainz] primary is- Multiple myeloma....and B cell Lymphoma... (AL)
[md90] with primary and secondary... carpal tunnel syndrome, hepatosplenomeglay, arrhythmia, heart failure...
[rainz] secondary.....(aa) rheumatoid arthritis, SLE, tb oseomylitis
[rainz] oh
[md90] but if they say that there is dementia r/t alzeimers or chromosome 21.. think amyloidosis..
[rainz] good question!
[rainz] very good question
[md90] immunoelectrophoresis can be used for primary.. and tissue biopsy from adipose and rectum
[md90] thanks...
[rainz] k
[rainz] you have Goljan 2006?
[md90] like goljan says.. it can be difficult to diagnose this b/c most times the patient is dead when you discover the problem..
[rainz] yea
[md90] i had the audio.. and the HY notes.. but I hated it...
[rainz] yea i have that too
[rainz] i listened to all of it all last week... i finished it a couple days ago
[md90] I'm very systematic.. in my approach to studying and reading... so I bought the goljan rapid review pathology... and it has helped so much
[rainz] HY i finished today...took me 2 days!
[rainz] oh
[rainz] well, watver works for you.
[rainz] i started studying subject wise
[md90] i listen to it every day.. even while I'm sleeping... it will go into my unconscious then to my conscious.. and into my dreams
[rainz] and then started systemic too
[rainz] lol
[rainz] seriously?
[md90]
[rainz] you wish
[rainz] lol
[md90] i didn't mean a sad face
[rainz] oh
[rainz] i listened to him once while sleeping
[rainz] but codnt recall nothing... i was KNOCKED out.
[md90] i listen to it.. i'll play in my computer.. and put the headphones on... repeat what he says..
[rainz] when i woke up ... the cell infury was done
[rainz] yea
[rainz] i put my headphones into my laptop
[rainz] and pause when i need to...
[rainz] write down wat i didnt know
[md90] then slowly drift to sleep.. and not to feel guilty for not studying.. I'll listen to it while doing exercise
[rainz] good
[md90] for the past couple of months.. I have been trying to beat him to the punch... by answering before he does..
[md90] that's how I know that I have been retaining..
[rainz] ok.. a patient comes in, with an intrinsic defect in B cell maturation, recurrent sinopulmonary infections, decresased Ig production. You also notice some giardia crawling. What is the dz?
[rainz] yea... thats wat i do too.
[md90] IgA def
[rainz] Its our fav- Common Variable immune def
[md90] that giardia crawling is throwing me for a loop.....
[md90] ok.. that's good, and figured how to differentiate btwn the two..
[rainz] actually
[rainz] they both have giardia
[rainz] i just looked at it now
[md90] b/c IgA has the sinopulmonary and decreased Ig..
[md90] it does..???
[rainz] so does CVID
[md90] back to the drawing board...
[md90] *)
[rainz] only thing is that IgA def develop anti IfA antibodies with exposeure to blood products
[md90] am looking it up...
[rainz] danger of ANAPHYLACTIC REACTION when exposed to IGa
[rainz] notice ... CVID- there is no decrease in IgA specifically...there is only a decrease in Ig
[md90] does IgA occur more in kids? because it states CVID is adult immunodef disorder?
[rainz] CVID- malabsorption due to celiac sprue
[md90] ok..
[md90] have to re-look at those two tonight...
[rainz] well im reading it in Goljan HY.. and he doesnt differenciate it...OK look.. CVID is has NO INHERITANCE PATTERN
[rainz] Selective IgA def - has INDERITANCE PATTERN
[rainz] its the most commone herititary immunodeficiency-- IgA
[rainz] sorry for the mispelling- i type really fast.
[rainz] without looking
[md90] the book states that.. that's why I was wondering...
[rainz] k
[md90] no worry.. if I don't get it, I'll ask you..
[rainz] sounds good
[rainz] yur a girl rite?
[md90] what is the differention between dermatomyositis and polymyositis?
[md90] yeah.. am a girl..why?
[rainz] dermatomysosisits= is around a group of vessels
[rainz] cuz you sound like me.
[rainz] i mean the things you say remind me of myself.
[md90] ur an indian right..
[rainz] lol
[rainz] howd you know
[rainz] yes i am
[rainz] wat bout you?
[md90] cuz I read your posts re: being sikh and movie posts..
[rainz] oh yea.
[md90] and connect with that.. b/c am indian..
[rainz] i accidentally reveal a lot about myself.. even tho mom says dont talk to strangers..LOL
[rainz] what type of indian are you?
[md90] i'm from south india.. born there but raised in Oklahoma... therefore am a southern indian gal
[rainz] i've never met one of those before
[md90] if you hear me talk.. can tell.. and that y'all comes out at the oddest times...
[rainz] LOL
[rainz] thats so funny.
[md90]
[rainz] ok, this polymyositis... i completely forgot.
[rainz] dermato-single...and poly- a lot
[rainz] i remember it along those lines
[rainz] vesicles?
[md90] remember.. with dermato.. involved with skin, and poly is not...
[rainz] ok
[rainz] you can see that from the name too rite?
[md90] right..
[rainz] im panicking
[rainz] lol
[md90] what about the pathology? there's difference there too..
[rainz] ok
[rainz] so
[md90] derm is antibody mediated.. and poly is ...
[rainz] polymyositis is endomysial lumphocytic inflammation
[md90] poly is t cell mediated..
[md90] sorry drew a blank..
[rainz] cytotoxic T8
[md90] actually I should say damage
[rainz] dermato is skin rash and upper eye lid also it is perimysial and vascular lymphocytic iinflammation
[md90] don't panic... you are doing great!!!
[rainz] i gotta review
[rainz] ok sooooo... argh! polymyositis is muscle weakness
[rainz] they both are muscle weaknesses
[md90] both of these are associated with women 40-60 years, risk of malignant neoplasms
[rainz] the difference is that dermo is a rash and eye edema
[md90] think "raccoon eyes"... purple red eyelid discolaration
[rainz] dermo the raccoon
[rainz] with weak muscles
[md90] both can have it.. but the dermato will involve the skin...
[rainz] yea.. and poly jus has the weak musces
[md90] the only difference is the skin involvement and pathology
[md90] wait.. lemme look it up..
[rainz] dermo is vascular eh?
[rainz] and poly is lympho only
[md90] according to goljan book.. the only difference is the skin involvement and pathology.. everything else is the same..
[rainz] ok
[rainz] thanks!
[rainz] how much more do you wanna do?
[md90] both will have muscle pain and atrophy.. involving the shoulders most common; lab findings: serum ANA, elevated serum CK, muscle biopsy
[rainz] great
[rainz] ANA...
[rainz] i didnt know that
[md90] ANA is positive < 30% of the cases.. is not a good relying factor..
[md90] it's up to you... think that we did a good job in immunopathology..
[rainz] lets keep going
[md90] i will post this in the USMLE CHATS...
[rainz] lol
[rainz] ok, they'll read where we bonded
[rainz] haha
[md90] do you know desensitization therapy?
[md90] I can cut that out if you want..
[rainz] its ok
[rainz] desensitization therapy?
[rainz] no
[rainz] never heard of it
[rainz] wat is it?
[md90] I forgot after I typed it.. so I had to flip the card..
[md90] it's repeated injections of allergen resulting in the production of IgG antibodies that attach to allergens and prevent them from binding to mast cells
[rainz] patiend comes in with recurrent pulmonary infections with P. aeruginosa, he has pancreatic insuffiecincy malodours steatorrhea, bronchiectasis and a deletion in postion 508. what ist he dz?
[md90] amounts of allergen are increased with each injections..
[md90] CF
[md90] cystic fibrosis
[rainz] wat chromosome?
[rainz] what protien?
[md90] chromosome 7
[rainz] what protein?
[md90] delta protein..
[rainz] what is the mc presenting symptom an infant would have with CF?
[md90] no.. delta 508
[rainz] not delta... its cholirde channel protein. CFtr
rainz has left the chat.
[md90] arrggghhh... i should know this... this was my paper for pathology.
[rainz] hello?
[rainz] im sorry... i dunno what happened
[rainz] you there?
[md90] meconium ileus
[rainz] good job
[md90] found in the infant...
[md90] CFTR
[rainz] ummm.. sorry- am i jumping?
[rainz] are we done immunopatho?
[md90] are you jumping..
[md90] can't see you.. how would I know..???
[rainz] i was doing some genetic disorders now
[rainz] Haha
[md90] lol
[md90] sorry.. have to keep it light...
[rainz] yea
[rainz] lol
[rainz] i like it
[rainz] its good
[rainz] ok
[rainz] so are we done immunopath?
[md90] this mutation shifts the reading frame of the DNA strand.. can be either deletion or insertion.. what is the mutation?
[md90] we are done with immuno.. but if you have more questions.. that is fine.. ask; we are here to learn..
[rainz] ummmm
[rainz] frameshift is fragile X
[rainz] but insertion, or deletion yur throwin me off
[md90] tay-sachs is another example
[rainz] hexosaminidase A
[md90] which is a 4-base insertion
[md90] straight from goljan book..
[md90] what is this one?...
[rainz] mmmmmmmmmmmmmmmmmmmm
[rainz] ?
[rainz] i dont remember
[rainz] wat is 4 base?
[md90] increasing severity in each successive generation, females may be symptomatic if they have more paternal derived X chromosomes with trinucleotide repeats..
[rainz] ive never heard oif a 4base insertion
[md90] i'm trying to see how I can explain it to you..
[rainz] ok
[rainz] cuz itnt it always 3 base pairs?
[md90] I looked it up when I first read it, but I can't find my notes..
[rainz] how do you get 4?
[md90] when you read a frame of DNA.. it's usually three right..
[rainz] yup
[md90] each 3codons represent an amino acid.. but let's say that we have ATTGTTCAGGTTACC
[rainz] k
[md90] where the first C is.. a G is inserted.. therefore making it.. ATT GTT CGA GGT ACC
[md90] or it could mis-read as four... CGAT..
[rainz] okok
[rainz] yea i know wat yur talking bout
[rainz] thanks!
[md90] or skip/delete the C
[rainz] so wat dz would be like that?
[rainz] i cannot recall
[md90] tay-sachs is a good example of insertion..
[rainz] ok
[rainz] thanks
[md90] b/c it results in the synthesis of a defective lysomsomal enzyme (hexosaminidase)
[rainz] ok
[rainz] what is the deficiency in I cell dz?
[rainz] and what are the presenting symptoms?
[md90] mannose 6 glucose
[rainz] wait... i thought it was phosphotransferase def?
[md90] and the lysosomes don't have the capabitlity to degrade.. and the person will show.. mental retardation and early death
[rainz] coarse facial features
[rainz] gingivitis- degraded gums
[md90] hold on..
[rainz] but...i thought it was phosphotransferase def?
[md90] we're talking about Inclusion (I) cell disease?
[rainz] yes
[md90] sorry.. it's mannose-6-phosphate marker... not glucose
[rainz] im confused now
[md90] everything else is right.. they don't have the hydrolytic enzymes to degrade and the undigested substrates accumulate as large inclusions in the cytosol..
[rainz] lysosomal dz are mannose 6 phosphate... i thought I cell dz was phosphotransferase def?
[rainz] ?????????????/
[md90] let me look it up..
[md90] i'm reading goljan..
[rainz] my kaplan biochem i have phosphotransferase written in there
[md90] i'm confused now too.. b/c I "googled" it... and it says phosphotransferase, and in goljan, it states mannose-6-phosphate..
[rainz] yea i goljan it says mannose 6 ph
[rainz] but i think its mannose 6 ph for lysosomal dz...any lysosmal
[md90] lemme ask you something.. what's the difference between stating "lack the mannose-6-phosphate marker" from deficiency?
[rainz] but its phosphotransferase for ICELL
stookie has left the chat.
[md90] is there a difference?
[rainz] hmmm
[rainz] i think they mean the same thing
[md90] i'm with you.. that it's phosphotransferase def..
[rainz] ok, i have it written in my biochem kaplan book
[rainz] i had it memorized like taht.
[md90] b/c I do remember reading that mannose-6-phosphate can be with all lysosomal dz..
[rainz] maybe phospohtransferase is a derivative of mannose 6 ph?
[rainz] yes i remember that too
[rainz] im sticking with phosphotransferase
[rainz] good! good! we are learning
[rainz] im scared of transgenic mice
[rainz] quesitons
[md90] I have the FA2006.. and it states that it's the failure of addition of mannose-6-phosphate to lysosome proteins..
[rainz] ohhh
[rainz] i guess it is mannose 6ph
[rainz] cant fight with FA2006
[rainz] so FA and Goljan say it
[rainz] it prolly is mannose then
[rainz] ok, im gunna go finish off myq-bank
[md90] according to webmd.. it is a mutation in the gene GNPTA which cause a def in the enzyme.. UDP...... phosphotransferase..
[rainz] ohhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh hhhhhhh
[rainz] NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
[md90] it was too long for me type...
[rainz] haha
[rainz] thats ok
[rainz] this is not god
[rainz] good
[md90] what's wrong..???
[rainz] if it is phosphotransferase of mannose?
[rainz] let me try emedicine
[rainz] no they dont have it
[rainz] i havent gotten a q-bank question on it yet
[md90] i'll research.. and post in USMLE chats...
[md90] if there is question about it.. USMLE won't have a question on it..
[md90] they can't afford over a million students writing in...
[rainz] ya
[md90] lol
[rainz] funny girl
[rainz] hey ... for yur rotations: www.emedicine.com will come in very handy
[rainz] just a some advice.
[md90] but.. i'll let you complete the qbank.., and am going to study for another hour and go to bed..
[md90] what advice...
[rainz] ok
[rainz] oh... i was jus talkin bout emedicine.com
[rainz] its good for clinicals
[md90] do you have to register for that?
[rainz] thanks for everything!
[rainz] yea
[rainz] its free
[md90] ok.. thanks appreciate that...
[rainz] good.
[md90] thank you..
[rainz] i've never studied like this b4
[rainz] its pretty helpful
[md90] tomorrow.. same time..
[rainz] i wish more people came
[rainz] ok
[rainz] sounds good
[rainz] good luck studying
[md90] there should be more people tomorrow.. one guy went to a wedding..
[md90] and there will be two others...
[rainz] joseph
[rainz] ok cool
[md90] yeah.. joseph
[rainz] maybe tomorrow will be more intense...LOL
[rainz] im sorry if this wasnt enough or sumthin
[rainz] it was my first time studying like this
[md90] we'll do environmental and nutritional pathology..
[md90] tomorrow..
[rainz] k
[rainz] cool
[md90] it was good.. thought that we did alot.. and we filled what the each of us did not know..
[rainz] yea.
[rainz] i agree
[rainz] this was useful
[rainz] thanks again!
[md90] ur welcome.. and thank you... have a good night..
[rainz] you too
[rainz] bye
[md90] bye
rainz has left the chat.

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