At a given PO2, more O2 can be unloaded from hemoglobin when which of the following is decreased in erythrocytes?
A) 2,3-Bisphosphoglycerate
B) pH
C) PCO2
D) Temperature
Final answer is B. Increase in H+ will decrease pH and this causes the shift of the oxygen disassociation curve to shift to the right and unload its O2.