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    pharmacology is offline Member
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    mechanism of action of amlodipine

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    A 72-year-old man is seen for an annual examination. His blood pressure is 170/100 mm Hg. His physician prescribes amlodipine. This agent exerts its mechanism of action through the blockade of which of the following?

    A. Alpha1 adrenergic receptors
    B. Angiotensin converting enzyme
    C. Beta1 receptors
    D. Beta2 receptors
    E. Calcium channels

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    stepanida is offline Junior Member
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    pharmacology is offline Member
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    Re: mechanism of action of amlodipine

    Quote Originally Posted by pharmacology
    A 72-year-old man is seen for an annual examination. His blood pressure is 170/100 mm Hg. His physician prescribes amlodipine. This agent exerts its mechanism of action through the blockade of which of the following?

    A. Alpha1 adrenergic receptors
    B. Angiotensin converting enzyme
    C. Beta1 receptors
    D. Beta2 receptors
    E. Calcium channels
    Good,

    A 72-year-old man is seen for an annual examination. His blood pressure is 170/100 mm Hg. His physician prescribes amlodipine. This agent exerts its mechanism of action through the blockade of which of the following?
    A. Alpha1 adrenergic receptors
    B. Angiotensin converting enzyme
    C. Beta1 receptors
    D. Beta2 receptors
    E. Calcium channels



    The correct answer is E. Amlodipine is a calcium channel-blocking agent indicated for the treatment of mild to moderate hypertension and angina. Amlodipine selectively blocks calcium ion influx across the membranes of cardiac and vascular smooth muscle cells without changing serum calcium concentrations.

    Terazosin is an example of an alpha-1 adrenergic receptor-blocking agent (choice A) that is indicated for the treatment of hypertension and benign prostatic hypertrophy.

    Enalapril is an example of an angiotensin converting enzyme (ACE) inhibitor (choice B) indicated for the treatment of hypertension and congestive heart failure. When ACE is inhibited, it prevents the conversion of angiotensin I to angiotensin II, leading to a decrease in aldosterone levels.

    Propranolol is an example of a non-selective beta-1 receptor (choice C) and beta-2 receptor (choice D) blocking agent indicated for the treatment of hypertension. Beta-1 receptor blockade leads to negative inotropic and chronotropic effects on the heart. Beta-2 receptor blockade causes bronchoconstriction.

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