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  1. #1
    rc3550 is offline Newbie 510 points
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    Mellaril (thioridizine) questions

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    I know it is use to help schizophrenics. BUT, if a person were not schizophrenic, instead given the drug by mistake, and were taking 400mg/day, what would the effect be on that person?

    RC

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    kstarhero is offline Newbie 510 points
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    Dosages of Thioridazine must be adjusted according to the individual. 400 mg daily is usual given to patients with severe disturbances, hospitalised patients. Effects include:

    CNS: drowsiness, sedation, hyperactivity, psychotic reactions, extrapyramidal reactions and dystonic reactions.
    CV: orthostatic hypothension, tachycardia and ECG changes
    ANS: dry mouth, fainting, miosis, blurred vision
    GI: nausea, vomiting, constipation, diarrhea

    Due to concerns about cardiotoxicity and retinopathy at high doses this drug is not commonly prescribed, reserved for patients who have failed to respond to the normal antipsychotics prescribed. Furthermore, the patient may have a fatal neuroleptic malignant syndrome. This is due to its dopamine-blocking and anti-cholinergic activity.

  3. #3
    rc3550 is offline Newbie 510 points
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    Quote Originally Posted by rc3550 View Post
    I know it is use to help schizophrenics. BUT, if a person were not schizophrenic, instead given the drug by mistake, and were taking 400mg/day, what would the effect be on that person?

    RC
    Thanks for that info. Is there any literature on this? I've looked a bit but not found anything useful.

    RON

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    kstarhero is offline Newbie 510 points
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    Quote Originally Posted by rc3550 View Post
    Thanks for that info. Is there any literature on this? I've looked a bit but not found anything useful.

    RON
    CV toxicities: Heath A, Svensson C, Martensson E (Apr 1985). "Thioridazine toxicity--an experimental cardiovascular study of thioridazine and its major metabolites in overdose". Veterinary and Human Toxicology 27 (2): 100–5.

    Effects of the drug in healthy patients:
    Clin Pharmacol Ther. 1996 Nov;60(5):543-53. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Hartigan-Go K, Bateman DN, Nyberg G, Mårtensson E, ****** SH.

  5. #5
    rc3550 is offline Newbie 510 points
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    Quote Originally Posted by kstarhero View Post
    cv toxicities: Heath a, svensson c, martensson e (apr 1985). "thioridazine toxicity--an experimental cardiovascular study of thioridazine and its major metabolites in overdose". Veterinary and human toxicology 27 (2): 100–5.

    Effects of the drug in healthy patients:
    Clin pharmacol ther. 1996 nov;60(5):543-53. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Hartigan-go k, bateman dn, nyberg g, mårtensson e, ****** sh.

    thanks hugely. This is very helpful.

    Ron

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