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  1. #1
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    Question regarding FLUTAMIDE

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    Hello, to every one

    my question is:

    how does FLUTAMIDE treat prostatic cancer though it increases LH and testosterone level ??

    and

    how does it cause gynecomastia if the androgen level is the one which increase ??

    i wish you could help in these ..
    "understanding like frindship takes time to develop"

  2. #2
    Hatim is offline Junior Member 510 points
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    i belive u have to give it with another drug goserlin to prevent the inital flare up from flutamide and then negative feed back kicks in.
    hope i'm rite any one else?

  3. #3
    SONALI SEN is offline Junior Member 510 points
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    Flutamide Is A Non Steroidal Compound And Essentially An "androgen Receptor Inhibitor"......so It Does Not Allow Androgen To Have Its Effect On Prostate.....and Therefore Helpful In The Treatment Of Prostate Cancer......
    And Since The Male Hormone Does Not Act On The Androgen Receptors Elsewhere In The Body....the Patient Tends To Have Gynaecomastia.....

  4. #4
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    Flutamide Is A Non Steroidal Compound And Essentially An "androgen Receptor Inhibitor"......so It Does Not Allow Androgen To Have Its Effect On Prostate.....and Therefore Helpful In The Treatment Of Prostate Cancer......
    thanx for the explanation

    And Since The Male Hormone Does Not Act On The Androgen Receptors Elsewhere In The Body....the Patient Tends To Have Gynaecomastia.....
    still not convinced
    "understanding like frindship takes time to develop"

  5. #5
    GFLIP's Avatar
    GFLIP is offline Senior Member 510 points
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    Aromatase converts the testosterone into estradiol. Excess estradiol leads to proliferation of breast tissue.

  6. #6
    SONALI SEN is offline Junior Member 510 points
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    thanks GFLIP....for the explanation.

  7. #7
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    ... glad to help ...

  8. #8
    azaheer's Avatar
    azaheer is offline Junior Member 510 points
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    Quote Originally Posted by GFLIP View Post
    Aromatase converts the testosterone into estradiol. Excess estradiol leads to proliferation of breast tissue.
    I dont wanna be a pain but :

    from where aromatase came from???

    thanx in advance







    "understanding like frindship takes time to develop"

  9. #9
    SONALI SEN is offline Junior Member 510 points
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    aromatase is an enzyme of cytP450 group whose function is to convert androstenidione to estrone...... and testosterone to estradiol.

    In humans gene cyp19 located on chr no 15q21 encodes for this enzyme.

    The enzyme aromatase is found in many organs including gonads ,brain,adipose tissue,placenta,blood vessels,skin,bone,endometrium.

    Aromatase converts testosterone to estradiol


    Aromatase converts androstenedione to estrone

  10. #10
    SONALI SEN is offline Junior Member 510 points
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    aromatase is an enzyme of cytP450 group whose function is to convert androstenidione to estrone...... and testosterone to estradiol.

    In humans gene cyp19 located on chr no 15q21 encodes for this enzyme.

    The enzyme aromatase is found in many organs including gonads ,brain,adipose tissue,placenta,blood vessels,skin,bone,endometrium.

    Aromatase converts testosterone to estradiol


    Aromatase converts androstenedione to estrone

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