Yes, there is lab; it's the only real lab you'll have besides the occasional trip down to see the cadavers in anatomy. Most others are simple smaller-group versions of lectures. I actually enjoyed the biochem lab a lot. As far as how difficult it is, you basically need to know Lippincott's Illustrated Review. A few sections are stressed, but Anatomy is far more demanding, as are most of your 2nd year courses. If you had biochem in undergrad it'll be a good review with a bit more detail. If you haven't you might want to read through Lippy's and start going over the cycles. Then again, reading over Anat will probably prove far more helpful.