Vancomycin PK

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Table Of Content

Vancomycin & Aminoglycoside Pharmacokinetics

Patient Information:

Drug :

Calculation :

Drug Infusion Time :

Current Weight :

Admit Weight :

Gender :

Age :

years

Serum Creatinine :

mg/dL

Height :

inches

Vancomycin Clearance :

References:

Young, Lloyd Y., and Koda-Kimble, Mary A. Applied Therapeutics: The Clinical Use of Drugs. 6th Edition. Vancouver: Applied Therapeutics, Inc., 1995.

Equations:

Initial Bolus-Model Equations

Initial Short-Infusion Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

Cp_ss max (mg/L) =

Dose	( e^{- kt} )

Vd

( 1 - e^{- kt} )

Cp_ss min (mg/L) =

Dose	( e^{- kt} )

Vd

( 1 - e^{- kt} )

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

Cp_ss max (mg/L) =

Dose	( 1 - e^{- kt}_in ) x e ^{- kt}₁

t_in x Cl

( 1 - e^{- kt} )

Cp_ss min (mg/L) =

Dose	( 1 - e^{- kt}_in ) x e ^{- kt}₂

t_in x Cl

( 1 - e^{- kt} )

Revision Bolus-Model Equations

Revision Short-Infusion Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

kel =

ln(

dose / Vd + C (trough)

C (trough)

)

Dose (mg) =

Cp_ss x Vd x ( 1 - e^{- kt} )

e^{- kt}

Cp_ss max (mg/L) =

Dose	( e^{- kt} )

Vd

( 1 - e^{- kt} )

Cp_ss min (mg/L) =

Dose	( e^{- kt} )

Vd

( 1 - e^{- kt} )

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

kel =

ln(

Cpss (peak)

Cpss (trough)

)

Cl (L/hr) =

Dose	( 1 - e^{- kt}_in ) x e^-^kt

Cpss x t_in

( 1 - e^{- kt} )

Dose (mg) =

Cp_ss x Cl x t_in x ( 1 - e^{- kt} )

( 1 - e^{- kt}_in) ( e^{- kt})

ss max (mg/L) =

Dose	( 1 - e^{- kt}_in ) x e ^{- kt}₁

t_in x Cl

( 1 - e^{- kt} )

Cp_ss min (mg/L) =

Dose	( 1 - e^{- kt}_in ) x e ^{- kt}₂

t_in x Cl

( 1 - e^{- kt} )

DISCLAIMER

DISCLAIMER: All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither ValueMD nor any other party involved in the preparation or publication of this site shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.

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