Several clinical trials have suggested that retenoic acid can induce remission in patients with acute promyelocytic leukemia . Such remission is related to the ability of retinoic acid to promote which of the following. A)Differentiation of leukemia cells
B)Differentiation of monocytes into macrophages
C)Generation of cyto toxic T lymphosites
D)Production of interferon
E)Repair of DNA damage
is it E??

retinoic acid is required for the growth ,differentiation and maintanance .
High doses of vit A may induce remission by maturing the cells.

I am going with A

APL is unique among the leukemias distinguished by its sensitivity to all-trans retinoic acid (ATRA), a derivative of vitamin A. Treatment with ATRA causes differentiation of the immature leukemic promyelocytes into mature granulocytes. ATRA is typically combined with anthracycline based chemotherapy resulting in a clinical remission in approximately 90% of patients.
ATRA therapy is associated with the unique side effect of retinoic acid syndrome. This is associated with the development of dyspnea, fever, weight gain, peripheral edema and is treated with dexamethasone. The etiology of retinoic acid syndrome has been attributed to capillary leak syndrome from cytokine release from the differentiating promyelocytes.

Ans: A

pappi has been right all along....his intergrations are great .
its A

the ans is A coz it causes maturation of the blast cells