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04-27-2006, 12:28 AM
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#29
What other anti-metabolites are used in the S-phase in cancer chemotherapy?
metoaptopurine and thioguanine--purine analogues that inhibit purine synthesis; azaacytidine--limits pyramidine synthesis by inhibiting orotidylate decarboxylase; hydroxyurea--inhibits formation of deoxyribonucleotides from ribonucleotides; 5-Fluorouracil--inhibits thymidylate synthase; cytarabine (AKA cytosine arabinoside)--inhibit DNA polymerase     
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